Hao Guanyu, Xu Zhi Ping, Li Li
Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland Brisbane Queensland Australia 4072
RSC Adv. 2018 Jun 19;8(39):22182-22192. doi: 10.1039/c8ra02095g. eCollection 2018 Jun 13.
The pH in tumour cells and the tumour microenvironment has played important roles in cancer development and treatment. It was thought that both the extracellular and intracellular pH values in tumours are acidic and lower than in normal cells. However, recent progress in the measurement of pH in tumour tissue has disclosed that the intracellular pH (pH) of cancer cells is neutral or even mildly alkaline compared to normal tissue cells. This review article has summarized the recent advancement in the measurement pH and extracellular pH (pH) in cancer cells, and the effect of pH and pH on proliferation, migration and biological functions of cancer cells. This paper has also elaborated recent treatment strategies to manipulate pH and pH for cancer treatment. Based on the recent progress in pH and pH manipulation in cancer treatment, we have proposed potential nanoparticle-based strategies to manipulate pH and pH to effectively treat cancer.
肿瘤细胞和肿瘤微环境中的pH值在癌症发展和治疗中发挥了重要作用。过去认为肿瘤细胞外和细胞内的pH值均呈酸性且低于正常细胞。然而，肿瘤组织pH测量的最新进展表明，与正常组织细胞相比，癌细胞的细胞内pH（pHi）呈中性甚至轻度碱性。这篇综述文章总结了癌细胞内pH和细胞外pH（pHe）测量的最新进展，以及pHi和pHe对癌细胞增殖、迁移和生物学功能的影响。本文还阐述了用于癌症治疗的调节pHi和pHe的最新治疗策略。基于癌症治疗中调节pHi和pHe的最新进展，我们提出了基于纳米颗粒的潜在策略来调节pHi和pHe以有效治疗癌症。
