Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF:Yb/Er nanoparticles.

NaGdF:Yb/Er nanoparticles were synthesized a modified hydrothermal route. The dependence of structure and morphology on the dosage of sodium polyacrylate was studied by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The as-prepared nanoparticles could be used for weighted magnetic resonance imaging due to the paramagnetism of Gd. -dichlorodiamineplatinum (CDDP) could be loaded onto NaGdF:Yb/Er nanoparticles through binding carboxyl in the form of Pt-O bonds, and doxorubicin (DOX) could be loaded hydrogen bonding. DOX could also be loaded onto the NaGdF-CDDP composite in the same manner, and the loading efficiency of both drugs remained unchanged. Three as-prepared drug delivery systems were used for tumor inhibition both and , and the results indicated that NaGdF-CDDP-DOX displayed the greatest inhibitory capacity.