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新型Pro-PYE配体作为钯催化的Heck-Mizoroki交叉偶联反应共催化剂的合成。

Synthesis of new Pro-PYE ligands as co-catalysts toward Pd-catalyzed Heck-Mizoroki cross coupling reactions.

作者信息

Munir Naima, Masood Sara, Liaqat Faroha, Tahir Muhammad Nawaz, Yousuf Sammer, Kalsoom Saima, Mughal Ehsan Ullah, Sumrra Sajjad Hussain, Maalik Aneela, Zafar Muhammad Naveed

机构信息

Department of Chemistry, Quaid-i-Azam University Islamabad-45320 Pakistan

Department of Physics, University of Sargodha Sargodha-40100 Pakistan.

出版信息

RSC Adv. 2019 Nov 21;9(65):37986-38000. doi: 10.1039/c9ra07912b. eCollection 2019 Nov 19.

DOI:10.1039/c9ra07912b
PMID:35541803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9075740/
Abstract

The present research work describes the synthesis of five new ligands containing pyridinium amine, [HL][OTf]-[HL][I] from two new precursors, [P ][I] and [P ][CFSO]. The structure elucidations of the compounds were confirmed by multinuclear NMR (H, C), FT-IR and by single crystal XRD techniques. Theoretical DFT studies were carried out to get better insight into the electronic levels and structural features of all the molecules. These synthesized new Pro-PYE ligands [HL][OTf]-[HL][I] were found to be significantly active as co-catalysts for Pd(CHCO) toward Heck-Mizoroki coupling reactions with wide substrate scope in the order of [HL][OTf] ≫ [HL][OTf] > [HL][OTf] > [HL][OTf] > [HL][I]

摘要

本研究工作描述了由两种新前体[P][I]和[P][CFSO]合成五个含吡啶胺的新配体[HL][OTf]-[HL][I]。通过多核NMR（H、C）、FT-IR和单晶XRD技术对化合物的结构进行了确证。开展了理论DFT研究以更好地洞察所有分子的电子能级和结构特征。发现这些合成的新型Pro-PYE配体[HL][OTf]-[HL][I]作为Pd(CHCO)用于Heck-Mizoroki偶联反应的共催化剂具有显著活性，底物范围广泛，活性顺序为[HL][OTf]≫[HL][OTf]>[HL][OTf]>[HL][OTf]>[HL][I]

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2
Computational Approach to Molecular Catalysis by 3d Transition Metals: Challenges and Opportunities.计算方法在 3d 过渡金属分子催化中的应用：挑战与机遇。
Chem Rev. 2019 Feb 27;119(4):2453-2523. doi: 10.1021/acs.chemrev.8b00361. Epub 2018 Oct 30.
3
Ligand "noninnocence" in coordination complexes vs. kinetic, mechanistic, and selectivity issues in electrochemical catalysis.
配位化合物中的配体“非惰性”与电化学催化中的动力学、机理和选择性问题。
Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9104-9109. doi: 10.1073/pnas.1810255115. Epub 2018 Aug 24.
4
Smart N-Heterocyclic Carbene Ligands in Catalysis.催化中的智能氮杂环卡宾配体
Chem Rev. 2018 Oct 10;118(19):9988-10031. doi: 10.1021/acs.chemrev.6b00695. Epub 2017 Feb 2.
5
Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions.钯催化的碳-氮交叉偶联反应的应用
Chem Rev. 2016 Oct 12;116(19):12564-12649. doi: 10.1021/acs.chemrev.6b00512. Epub 2016 Sep 30.
6
Donor-Flexible Nitrogen Ligands for Efficient Iridium-Catalyzed Water Oxidation Catalysis.用于高效铱催化水氧化催化的供体柔性氮配体
Chemistry. 2016 May 10;22(20):6740-5. doi: 10.1002/chem.201600875. Epub 2016 Apr 5.
7
Non-innocent ligands.非无害配体。
Chem Commun (Camb). 2015 Jan 31;51(9):1553-4. doi: 10.1039/c4cc90480j.
8
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9
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10
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Angew Chem Int Ed Engl. 2012 May 21;51(21):5062-85. doi: 10.1002/anie.201107017. Epub 2012 May 9.