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使用发射可调谐共轭聚合物纳米颗粒的细胞成像。

Cellular imaging using emission-tuneable conjugated polymer nanoparticles.

作者信息

Bourke Struan, Teijeiro Gonzalez Yurema, Donà Federico, Panamarova Maryna, Suhling Klaus, Eggert Ulrike, Dailey Lea Ann, Zammit Peter, Green Mark A

机构信息

Department of Physics, King's College London London WC2R 2LS UK

Randall Division of Cell and Molecular Biophysics, Faculty of Life Sciences and Medicine, New Hunt's House, King's College London Guy's Campus London SE1 1UL UK.

出版信息

RSC Adv. 2019 Nov 20;9(65):37971-37976. doi: 10.1039/c9ra07983a. eCollection 2019 Nov 19.

Abstract

New materials that exhibit tuneable optical properties, notable emission across the visible spectrum, are of immense interest to biologists as they present a broad palette of colours from a single imaging agent that can be utilised in biological detection. Such a flexible system, when combined with the advantages of using conjugated polymer nanoparticles in cell imaging results in a widely useful medical diagnostic system. Here, we describe tuneable emission observed through oxidation of a conjugated polymer followed by the formation of nanoparticles and their subsequent use in cell imaging.

摘要

具有可调节光学特性、在可见光谱范围内有显著发射的新型材料,引起了生物学家的极大兴趣,因为它们从单一成像剂呈现出广泛的颜色调色板,可用于生物检测。这样一个灵活的系统,当与在细胞成像中使用共轭聚合物纳米颗粒的优点相结合时,会产生一个广泛有用的医学诊断系统。在这里,我们描述了通过共轭聚合物氧化、随后形成纳米颗粒以及它们随后在细胞成像中的应用所观察到的可调节发射。

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