Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Medicine, Linyi University, Linyi 276005, China.
College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China.
Molecules. 2023 Jun 29;28(13):5091. doi: 10.3390/molecules28135091.
Conjugated polymers (CPs) have attracted much attention in the fields of chemistry, medicine, life science, and material science. Researchers have carried out a series of innovative researches and have made significant research progress regarding the unique photochemical and photophysical properties of CPs, expanding the application range of polymers. CPs are polymers formed by the conjugation of multiple repeating light-emitting units. Through precise control of their structure, functional molecules with different properties can be obtained. Fluorescence probes with different absorption and emission wavelengths can be obtained by changing the main chain structure. By modifying the side chain structure with water-soluble groups or selective recognition molecules, electrostatic interaction or specific binding with specific targets can be achieved; subsequently, the purpose of selective recognition can be achieved. This article reviews the research work of CPs in cell imaging, tumor diagnosis, and treatment in recent years, summarizes the latest progress in the application of CPs in imaging, tumor diagnosis, and treatment, and discusses the future development direction of CPs in cell imaging, tumor diagnosis, and treatment.
共轭聚合物（CPs）在化学、医学、生命科学和材料科学领域引起了广泛关注。研究人员对 CPs 的独特光化学和光物理特性进行了一系列创新性研究，并取得了重大研究进展，扩展了聚合物的应用范围。CPs 是由多个重复发光单元共轭形成的聚合物。通过对其结构的精确控制，可以获得具有不同性质的功能分子。通过改变主链结构，可以获得具有不同吸收和发射波长的荧光探针。通过用水溶性基团或选择性识别分子修饰侧链结构，可以与特定目标进行静电相互作用或特异性结合，从而实现选择性识别的目的。本文综述了近年来 CPs 在细胞成像、肿瘤诊断和治疗方面的研究工作，总结了 CPs 在成像、肿瘤诊断和治疗方面的最新应用进展，并讨论了 CPs 在细胞成像、肿瘤诊断和治疗方面的未来发展方向。
