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芳基萘内酯类似物:作为未来药物发现的优秀生物候选物的合成与开发

Arylnaphthalene lactone analogues: synthesis and development as excellent biological candidates for future drug discovery.

作者信息

Zhao Chuang, Rakesh K P, Mumtaz Saira, Moku Balakrishna, Asiri Abdullah M, Marwani Hadi M, Manukumar H M, Qin Hua-Li

机构信息

Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology 205 Luoshi Road Wuhan 430073 PR China

Sri Ram Chem, R & D Centre Plot No. 31, JCK Industrial Park, Belagola Industrial Area Mysore 570016 Karnataka India.

出版信息

RSC Adv. 2018 Mar 6;8(17):9487-9502. doi: 10.1039/c7ra13754k. eCollection 2018 Feb 28.

Abstract

Arylnaphthalene lactones are natural products extracted from a wide range of different parts of plants. The progressing interest in the synthesis of these compounds is due to their significant biological activities, which have made them potential candidates in drug discovery and development. This review mainly covers recent developments in the synthesis and biological applications of arylnaphthalene lactone analogs.

摘要

芳基萘内酯是从植物的多种不同部位提取的天然产物。对这些化合物合成的兴趣与日俱增,这是由于它们具有显著的生物活性,使其成为药物研发中有潜力的候选物。本综述主要涵盖芳基萘内酯类似物的合成及生物学应用方面的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac0e/9078642/222abcce87e9/c7ra13754k-f1.jpg

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