Liu Zhiguo, Zheng Xilong, Wang Yanan, Tang Mengyue, Chen Shilin, Zhang Fangbo, Li Li, Zhang Cun, Sun Yi
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700 PR China
Hainan Branch Institute of Medical Plant Development, Chinese Academy of Medical Sciences Wanning 571100 PR China.
RSC Adv. 2018 May 3;8(29):16383-16391. doi: 10.1039/c8ra02240b. eCollection 2018 Apr 27.
Twelve new compounds including four isoflavonolignans (1a/1b and 2a/2b), two neolignans (3a/3b), and six isoflavonoids (5-10), together with seven known compounds (4 and 11-16) were isolated from the stems of . The structures were elucidated on the basis of comprehensive spectroscopic analyses and ECD calculation methods. Compounds 1-3 were present as enantiomers that were successfully separated by chiral HPLC. Compounds 1a/1b and 2a/2b are the first examples of isoflavonolignans with a pyranoid ring linking up the isoflavonoid and the monolignol from nature. A putative biosynthetic pathway for the isoflavonolignans was deduced. The anti-inflammatory and cytotoxic activities for all compounds were evaluated.
从……的茎中分离出12种新化合物，包括4种异黄酮木脂素（1a/1b和2a/2b）、2种新木脂素（3a/3b）和6种异黄酮（5 - 10），以及7种已知化合物（4和11 - 16）。通过综合光谱分析和ECD计算方法阐明了其结构。化合物1 - 3以对映体形式存在，通过手性HPLC成功分离。化合物1a/1b和2a/2b是自然界中首次出现的具有连接异黄酮和单木质醇的吡喃环的异黄酮木脂素实例。推导了异黄酮木脂素的假定生物合成途径。评估了所有化合物的抗炎和细胞毒性活性。
