Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
Fitoterapia. 2022 Jul;160:105216. doi: 10.1016/j.fitote.2022.105216. Epub 2022 May 13.
Seven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated for neuroprotective effects toward human neuroblastoma SH-SY5Y cells injury induced by HO. Among them, compound 1a exhibited moderate protective effect.
从山楂果实中分离得到 7 种木脂素（1a/1b-2a/2b 和 3-5），包括 6 种新化合物（1b、2a/2b、3-5）。通过综合光谱分析阐明了它们的结构。化合物 1b/1b-2a/2b 是两对对映异构体，通过比较其实验和计算的 ECD 光谱确定了它们的绝对构型。此外，生物信息学分析表明，超过三分之一的疾病与神经系统有关。因此，所有化合物均针对 HO 诱导的人神经母细胞瘤 SH-SY5Y 细胞损伤进行了神经保护作用评估。其中，化合物 1a 表现出中等的保护作用。
