• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

功能化聚合物二醛糊精网络包覆的介孔二氧化硅纳米粒子用于pH/谷胱甘肽双控药物释放。

Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release.

作者信息

Chen Chao, Sun Wen, Yao Wenji, Wang Yibing, Ying Hanjie, Wang Ping

机构信息

State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, Biomedical Nanotechnology Center, School of Biotechnology, East China University of Science and Technology Shanghai 200237 People's Republic of China

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University Puzhu South Road Nanjing 211816 People's Republic of China

出版信息

RSC Adv. 2018 Jun 7;8(37):20862-20871. doi: 10.1039/c8ra03163k. eCollection 2018 Jun 5.

DOI:10.1039/c8ra03163k
PMID:35542325
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9080849/
Abstract

Multi-stimulation responsive nanomaterial-based drug delivery systems promise enhanced therapeutic efficacy in cancer therapy. This work examines a smart pH/GSH dual-responsive drug delivery system by using dialdehyde dextrin (DAD) end-capped mesoporous silica nanoparticles (MSNs). Specifically, DAD was applied as a "gatekeeper polymer" agent to seal drug loads inside the mesoporous of MSNs a pH-sensitive Schiff bond, whereas the formed DAD polymer shells were further cross-linked by GSH-sensitive disulfide bonds. Results revealed that the DAD gatekeeper polymer could tightly close the mesopores of MSNs to control premature drug release under physiological conditions and respond to acidic and GSH conditions to release the trapped drugs. Significantly, fluorescent microscopy observation and cytotoxicity studies indicated that drug-loaded nanoparticles could be rapidly internalized through a passive targeting effect to inhibit cancer growth. Taken together, these polymer-modified pH/GSH dual-responsive MSNs could be used as promising candidates for "on-demand" anticancer drug delivery applications.

摘要

基于多刺激响应纳米材料的药物递送系统有望在癌症治疗中提高治疗效果。这项工作通过使用端接二醛糊精（DAD）的介孔二氧化硅纳米颗粒（MSN）来研究一种智能pH/谷胱甘肽（GSH）双响应药物递送系统。具体而言，DAD作为一种“守门人聚合物”试剂，通过pH敏感的席夫碱将药物负载密封在MSN的介孔内，而形成的DAD聚合物壳层则通过GSH敏感的二硫键进一步交联。结果表明，DAD守门人聚合物可以紧密关闭MSN的介孔，以控制生理条件下药物的过早释放，并对酸性和GSH条件作出响应以释放被捕获的药物。重要的是，荧光显微镜观察和细胞毒性研究表明，载药纳米颗粒可通过被动靶向效应迅速内化以抑制癌症生长。综上所述，这些聚合物修饰的pH/GSH双响应MSN可作为“按需”抗癌药物递送应用的有前途的候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/e6cbe7e796b3/c8ra03163k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/c29ce8c263e3/c8ra03163k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/0dffae421447/c8ra03163k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/c74d12f96a44/c8ra03163k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/7789faba1844/c8ra03163k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/1ca2c1f6687e/c8ra03163k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/c73a33423977/c8ra03163k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/ecabeb7488f3/c8ra03163k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/e6cbe7e796b3/c8ra03163k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/c29ce8c263e3/c8ra03163k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/0dffae421447/c8ra03163k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/c74d12f96a44/c8ra03163k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/7789faba1844/c8ra03163k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/1ca2c1f6687e/c8ra03163k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/c73a33423977/c8ra03163k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/ecabeb7488f3/c8ra03163k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a74/9080849/e6cbe7e796b3/c8ra03163k-f7.jpg

相似文献

1
Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release.功能化聚合物二醛糊精网络包覆的介孔二氧化硅纳米粒子用于pH/谷胱甘肽双控药物释放。
RSC Adv. 2018 Jun 7;8(37):20862-20871. doi: 10.1039/c8ra03163k. eCollection 2018 Jun 5.
2
Fabrication of biodegradable auto-fluorescent organosilica nanoparticles with dendritic mesoporous structures for pH/redox-responsive drug release.具有树枝状介孔结构的可生物降解自荧光有机硅纳米粒子的制备及其用于 pH/氧化还原响应型药物释放。
Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110914. doi: 10.1016/j.msec.2020.110914. Epub 2020 Apr 1.
3
pH-responsive nanoreservoirs based on hyaluronic acid end-capped mesoporous silica nanoparticles for targeted drug delivery.基于透明质酸封端介孔硅纳米粒子的 pH 响应型纳米储库用于靶向药物递送。
Int J Biol Macromol. 2018 May;111:1106-1115. doi: 10.1016/j.ijbiomac.2018.01.093. Epub 2018 Jan 31.
4
pH-Sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles.基于改性糊精包覆介孔二氧化硅纳米粒子的pH敏感药物递送系统。
Int J Biol Macromol. 2016 Apr;85:596-603. doi: 10.1016/j.ijbiomac.2016.01.038. Epub 2016 Jan 14.
5
Polyaspartic acid-anchored mesoporous silica nanoparticles for pH-responsive doxorubicin release.用于pH响应性阿霉素释放的聚天冬氨酸锚定介孔二氧化硅纳米粒子
Int J Nanomedicine. 2018 Feb 19;13:1029-1040. doi: 10.2147/IJN.S146955. eCollection 2018.
6
Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications.用于pH刺激响应型药物递送应用的表面封端介孔二氧化硅纳米颗粒的合成。
Medchemcomm. 2017 Jul 13;8(9):1797-1805. doi: 10.1039/c7md00270j. eCollection 2017 Sep 1.
7
Unsaturated nitrogen-rich polymer poly(l-histidine) gated reversibly switchable mesoporous silica nanoparticles using "graft to" strategy for drug controlled release.采用“接枝到”策略制备的基于不饱和富氮聚合物聚（L-组氨酸）的可还原开关介孔硅纳米粒子用于药物控制释放。
Acta Biomater. 2017 Nov;63:150-162. doi: 10.1016/j.actbio.2017.08.050. Epub 2017 Sep 2.
8
pH-Sensitive Drug Delivery System Based on Mesoporous Silica Modified with Poly-L-Lysine (PLL) as a Gatekeeper.基于聚-L-赖氨酸（PLL）修饰的介孔硅的 pH 敏感药物传递系统作为守门员。
J Nanosci Nanotechnol. 2020 Nov 1;20(11):6925-6934. doi: 10.1166/jnn.2020.18821.
9
pH-Responsive and Biodegradable ZnO-Capped Mesoporous Silica Composite Nanoparticles for Drug Delivery.用于药物递送的pH响应性和可生物降解的氧化锌包覆介孔二氧化硅复合纳米粒子
Materials (Basel). 2020 Sep 7;13(18):3950. doi: 10.3390/ma13183950.
10
Redox and pH dual-responsive PEG and chitosan-conjugated hollow mesoporous silica for controlled drug release.用于控释药物的氧化还原和pH双重响应性聚乙二醇与壳聚糖共轭的中空介孔二氧化硅
Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:26-33. doi: 10.1016/j.msec.2016.04.091. Epub 2016 Apr 28.

引用本文的文献

1
Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems.受生物启发的细胞外囊泡包被二氧化硅纳米颗粒作为选择性递送系统
Mater Today Bio. 2023 Oct 29;23:100850. doi: 10.1016/j.mtbio.2023.100850. eCollection 2023 Dec.
2
Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery.天然生物聚合物作为介孔二氧化硅纳米粒子用于药物递送的智能涂层材料
Pharmaceutics. 2023 Jan 29;15(2):447. doi: 10.3390/pharmaceutics15020447.
3
Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications.

本文引用的文献

1
Disulfide-gated mesoporous silica nanoparticles designed for two-photon-triggered drug release and imaging.用于双光子触发药物释放和成像的二硫键门控介孔二氧化硅纳米粒子。
J Mater Chem B. 2015 Aug 21;3(31):6456-6461. doi: 10.1039/c5tb00797f. Epub 2015 Jul 13.
2
Redox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapy.用于癌症治疗中靶向药物递送的氧化还原刺激响应性中空介孔二氧化硅纳米载体
Nanoscale Horiz. 2016 Nov 17;1(6):480-487. doi: 10.1039/c6nh00139d. Epub 2016 Sep 9.
3
Rational design of curcumin loaded multifunctional mesoporous silica nanoparticles to enhance the cytotoxicity for targeted and controlled drug release.
利用介孔二氧化硅纳米粒子合成及表面功能化的最新趋势，以用于生物医学应用。
Int J Pharm X. 2022 Apr 19;4:100116. doi: 10.1016/j.ijpx.2022.100116. eCollection 2022 Dec.
4
Fourier transform and near infrared dataset of dialdehyde celluloses used to determine the degree of oxidation with chemometric analysis.用于通过化学计量分析确定氧化程度的二醛纤维素的傅里叶变换和近红外数据集。
Data Brief. 2021 Dec 23;40:107757. doi: 10.1016/j.dib.2021.107757. eCollection 2022 Feb.
5
Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates.用于癌症治疗的氧化还原响应性介孔二氧化硅纳米颗粒：最新进展
Nanomaterials (Basel). 2021 Aug 28;11(9):2222. doi: 10.3390/nano11092222.
载姜黄素的多功能介孔硅纳米粒子的合理设计，以增强靶向和控制药物释放的细胞毒性。
Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:88-96. doi: 10.1016/j.msec.2017.12.007. Epub 2017 Dec 18.
4
Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications.介孔硅和有机硅纳米粒子：物理化学、生物安全性、传递策略及生物医学应用。
Adv Healthc Mater. 2018 Feb;7(4). doi: 10.1002/adhm.201700831. Epub 2017 Nov 30.
5
pH-Sensitive Delivery Vehicle Based on Folic Acid-Conjugated Polydopamine-Modified Mesoporous Silica Nanoparticles for Targeted Cancer Therapy.基于叶酸修饰的聚多巴胺改性介孔硅纳米粒子的 pH 敏感型递药载体用于靶向癌症治疗。
ACS Appl Mater Interfaces. 2017 Jun 7;9(22):18462-18473. doi: 10.1021/acsami.7b02457. Epub 2017 May 22.
6
pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin.pH响应性聚（丙烯酸）门控介孔二氧化硅及其在阿霉素口服结肠靶向给药中的应用。
Colloids Surf B Biointerfaces. 2017 Jun 1;154:287-296. doi: 10.1016/j.colsurfb.2017.03.024. Epub 2017 Mar 14.
7
Redox-responsive mesoporous selenium delivery of doxorubicin targets MCF-7 cells and synergistically enhances its anti-tumor activity.载阿霉素介孔硒的氧化还原响应性递药靶向 MCF-7 细胞并协同增强其抗肿瘤活性。
Acta Biomater. 2017 May;54:294-306. doi: 10.1016/j.actbio.2017.02.042. Epub 2017 Mar 4.
8
Ingenious pH-sensitive dextran/mesoporous silica nanoparticles based drug delivery systems for controlled intracellular drug release.基于具有pH敏感性的葡聚糖/介孔二氧化硅纳米粒子的智能药物递送系统用于细胞内药物的可控释放。
Int J Biol Macromol. 2017 May;98:691-700. doi: 10.1016/j.ijbiomac.2017.01.136. Epub 2017 Feb 4.
9
Transferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery.转铁蛋白门控介孔二氧化硅纳米粒子用于氧化还原响应性靶向药物递送
Colloids Surf B Biointerfaces. 2017 Apr 1;152:77-84. doi: 10.1016/j.colsurfb.2017.01.010. Epub 2017 Jan 8.
10
Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles.硅、有机硅、硅倍半氧烷、二氧化硅混合氧化物和介孔硅纳米粒子的降解性和清除率。
Adv Mater. 2017 Mar;29(9). doi: 10.1002/adma.201604634. Epub 2017 Jan 13.