用于药物递送的pH响应性和可生物降解的氧化锌包覆介孔二氧化硅复合纳米粒子
pH-Responsive and Biodegradable ZnO-Capped Mesoporous Silica Composite Nanoparticles for Drug Delivery.
作者信息
Chen Minmin, Hu Jinxia, Bian Cancan, Zhu Chenghao, Chen Chen, Guo Zhijun, Zhang Zhimin, Agyekum Godfred Amfo, Zhang Zhuoqi, Cao Xichuan
机构信息
School of Materials and Physics, China University of Mining and Technology, Xuzhou 221116, China.
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, China.
出版信息
Materials (Basel). 2020 Sep 7;13(18):3950. doi: 10.3390/ma13183950.
As a drug delivery system (DDS), traditional mesoporous silica nanoparticles (MSNs) suffer from bioaccumulation in vivo and premature drug release in systemic circulation due to low degradation rate and lack of protective gatekeeper. Herein, we developed a safe and intelligent DDS with characteristics of pH-responsive biodegradation and controlled drug release based on mesoporous silica composite nanoparticles (MSCNs) capped with ZnO quantum dots (ZnO QDs). Acidic degradable MSCNs were successfully synthesized by doping Ca and PO into the MSNs' framework. The in vitro doxorubicin hydrochloride (DOX) release was inhibited at neutral pH 7.4 but triggered significantly at pH 5.0 due to the dissociation of ZnO caps. The internalization behavior and cytotoxicity of 4T1 cells indicated MSCNs-ZnO could efficiently deliver DOX into the cells with significant antitumor activity. Such a DDS with pH-responsive biodegradation and controlled drug release has promising potential for cancer therapy.
作为一种药物递送系统（DDS），传统的介孔二氧化硅纳米颗粒（MSN）由于降解速率低且缺乏保护性的“守门人”，在体内会发生生物蓄积，并在体循环中过早释放药物。在此，我们基于包覆有氧化锌量子点（ZnO QD）的介孔二氧化硅复合纳米颗粒（MSCN），开发了一种具有pH响应性生物降解和药物控释特性的安全智能DDS。通过将钙和磷掺杂到MSN的骨架中，成功合成了酸性可降解的MSCN。由于ZnO帽的解离，在中性pH 7.4时，盐酸阿霉素（DOX）的体外释放受到抑制，但在pH 5.0时显著触发释放。4T1细胞的内化行为和细胞毒性表明，MSCN-ZnO能够有效地将DOX递送至细胞内，并具有显著的抗肿瘤活性。这种具有pH响应性生物降解和药物控释功能的DDS在癌症治疗方面具有广阔的应用前景。
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