Ripoll Manon, Pierdant Marie, Neuberg Patrick, Bagnard Dominique, Wagner Alain, Kichler Antoine, Remy Jean-Serge
University of Strasbourg, CNRS, UMR7199, Labex Medalis, icFRC 67400 Illkirch France
MN3T Lab, Fédération de Médecine Translationnelle, Labex Medalis, INSERM U1109, University of Strasbourg 67400 Illkirch France.
RSC Adv. 2018 Jun 6;8(37):20758-20763. doi: 10.1039/c8ra03375g. eCollection 2018 Jun 5.
Recently, it has been shown that the efficiency of antitumoral drugs can be enhanced when combined with therapeutic siRNAs. In the present study, an original platform based on polydiacetylenic micelles containing a cationic head group able to efficiently deliver a small interfering RNA (siRNA) targeting the PLK-1 gene while offering a hydrophobic environment for encapsulation of lipophilic drugs such as camptothecin is developed. We demonstrate that the co-delivery of these two agents with our micellar system results in a synergistic tumor cell killing of cervical and breast cancer cell lines . The combined drugs are active in a subcutaneous cancer model. Altogether, the results show that our nanometric micellar delivery system can be used for the development of new drug-siRNA combo-therapies.
最近的研究表明，抗肿瘤药物与治疗性小干扰RNA（siRNA）联合使用时，其疗效可以得到增强。在本研究中，我们开发了一种基于聚二乙炔胶束的原始平台，该胶束含有一个阳离子头部基团，能够有效地递送靶向PLK-1基因的小干扰RNA（siRNA），同时为喜树碱等亲脂性药物的包封提供疏水环境。我们证明，使用我们的胶束系统共同递送这两种药物会导致对宫颈和乳腺癌细胞系产生协同的肿瘤细胞杀伤作用。联合药物在皮下癌模型中具有活性。总的来说，结果表明我们的纳米胶束递送系统可用于开发新的药物-siRNA联合疗法。
