酵母GCN4调节蛋白的DNA结合结构域与癌基因jun编码的蛋白质的羧基末端区域之间的同源性。
Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.
作者信息
Vogt P K, Bos T J, Doolittle R F
出版信息
Proc Natl Acad Sci U S A. 1987 May;84(10):3316-9. doi: 10.1073/pnas.84.10.3316.
Abstract
The product of the recently described oncogene jun shows significant amino acid sequence homology with the GCN4 yeast transcriptional activator protein. The similarity is restricted to the 66 carboxyl-terminal amino acids, thought to be the DNA-binding domain of the GCN4 protein. In these alpha-helix-permissive regions of the jun and GCN4 products there is also a lesser but still significant amino acid resemblance to the fos protein and a marginal degree of similarity to myc proteins. The amino acid sequence homology between GCN4 and jun gene products suggests that the jun protein may bind to DNA in a sequence-specific way and exert a regulatory function.
摘要
最近描述的癌基因jun的产物与GCN4酵母转录激活蛋白显示出显著的氨基酸序列同源性。这种相似性仅限于66个羧基末端氨基酸，被认为是GCN4蛋白的DNA结合结构域。在jun和GCN4产物的这些α-螺旋允许区域，与fos蛋白也存在较小但仍显著的氨基酸相似性，与myc蛋白有一定程度的相似性。GCN4和jun基因产物之间的氨基酸序列同源性表明，jun蛋白可能以序列特异性方式与DNA结合并发挥调节功能。
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