用于双重化学-光动力疗法的自组装有机纳米棒

Li Yuanyuan, Hu Xiuli, Zheng Xiaohua, Liu Yang, Liu Shi, Yue Ying, Xie Zhigang

The First Hospital of Jilin University Xinmin Street Changchun Jilin 130021 PR China

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China

RSC Adv. 2018 Feb 1;8(10):5493-5499. doi: 10.1039/c8ra00067k. eCollection 2018 Jan 29.

Photodynamic therapy (PDT) and chemotherapy have been extensively developed as effective approaches against cancer. Herein, we constructed organic nanorods by rational co-assembly of photosensitizer, di-iodinated borondipyrromethene (BDP-I), and chemical anticancer drug, paclitaxel (PTX). The physico- and photochemical properties of the obtained nanorods were carefully investigated. BDP-I was selected for its high singlet oxygen (O) quantum yields. And the corresponding O generation ability and photodynamic effect were evaluated both and . The accelerated endosomal escape of the nanorods induced by the photodynamic effect enhanced the chemotherapeutic efficacy of PTX. We believe that this synergetic nanomedicine represents a new development for antitumor chemophotodynamic therapy.

光动力疗法（PDT）和化疗已被广泛开发为对抗癌症的有效方法。在此，我们通过合理共组装光敏剂二碘化硼二吡咯亚甲基（BDP-I）和化学抗癌药物紫杉醇（PTX）构建了有机纳米棒。对所得纳米棒的物理和光化学性质进行了仔细研究。选择BDP-I是因为其具有高单线态氧（O）量子产率。并在体外和体内评估了相应的O生成能力和光动力效应。光动力效应诱导的纳米棒加速内体逃逸增强了PTX的化疗疗效。我们相信这种协同纳米药物代表了抗肿瘤化学光动力疗法的新进展。