Zhang Jianxu, Wang Lei, Xie Zhigang
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, People's Republic of China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
ACS Biomater Sci Eng. 2018 Jun 11;4(6):1969-1975. doi: 10.1021/acsbiomaterials.7b00470. Epub 2017 Aug 10.
Constructing organic nanorods with a uniform and tunable size is challenging. Herein, we fabricated borondipyrromethene (BODIPY) nanorods (BDP-NRs) via a simple single-step reprecipitation method in the absence of surfactants or adjuvants. The length and aspect ratio of the BDP-NRs could be tuned by varying the concentration of BDP. In addition, the obtained BDP-NRs are crystalline and stable in aqueous solution for several weeks. The formation mechanism of BDP-NRs was investigated in detail and ascribed to the crystallinity-induced assembly. More important, the BDP-NRs demonstrated efficient cellular uptake by living cells and a better imaging performance than free BDP, which contribute to a decrease in dosage of fluorescent dyes for bioimaging. This simple fabrication process with the ability to generate nanorods may open a new avenue in the development of organic fluorescence nanomaterials.
构建尺寸均匀且可调控的有机纳米棒具有挑战性。在此，我们在无表面活性剂或助剂的情况下，通过简单的一步再沉淀法制备了硼二吡咯亚甲基（BODIPY）纳米棒（BDP-NRs）。BDP-NRs的长度和纵横比可通过改变BDP的浓度来调控。此外，所获得的BDP-NRs具有晶体结构，且在水溶液中可稳定存在数周。我们详细研究了BDP-NRs的形成机制，并将其归因于结晶诱导组装。更重要的是，BDP-NRs在活细胞中表现出高效的细胞摄取，且成像性能优于游离BDP，这有助于减少用于生物成像的荧光染料剂量。这种能够生成纳米棒的简单制备工艺可能为有机荧光纳米材料开发开辟一条新途径。
