一种新型的谷胱甘肽触发的用于活细胞抗癌和成像的诊疗前体药物。

Zhang Hengrui, Fang Zhijie

School of Chemical Engineering, Nanjing University of Science & Technology 200 Xiao Ling Wei Nanjing 210094 P. R. China

RSC Adv. 2018 Mar 22;8(21):11419-11423. doi: 10.1039/c8ra00271a. eCollection 2018 Mar 21.

A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D and could be monitored by cellular imaging.

通过将萘二甲酰亚胺衍生物与维生素D用二硫键连接，设计并合成了一种新型的诊疗前药。该前药具有对谷胱甘肽（GSH）的高选择性检测过程，并在30分钟内显示出红移荧光。值得注意的是，它还表现出与维生素D相似的抗肿瘤活性，并且可以通过细胞成像进行监测。