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丁香酚通过内源性凋亡途径触发CD11bGr1髓源性抑制细胞凋亡。

Eugenol triggers CD11bGr1 myeloid-derived suppressor cell apoptosis endogenous apoptosis pathway.

作者信息

Ding Ying, Yang Zecheng, Zhang Wensheng, Xu Yuwei, Wang Yuanyuan, Hu Minghua, Ma Fangli, Long Hanan, Tao Ning, Qin Zhihai

机构信息

School of Basic Medical Sciences of Southwest Medical University Luzhou China.

College of Life Science, University of the Chinese Academy of Sciences Beijing China.

出版信息

RSC Adv. 2018 Jan 19;8(7):3833-3838. doi: 10.1039/c7ra13499a. eCollection 2018 Jan 16.

DOI:10.1039/c7ra13499a
PMID:35542913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077712/
Abstract

To study the effect and underlying molecular mechanism of eugenol on CD11bGr1 myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the pro-apoptosis effect of eugenol on MDSCs. The expression levels of apoptosis-related proteins were detected by western blot. Eugenol has a selective inhibitory effect on MDSCs in a dose-dependent manner, which activates an endogenous apoptosis pathway, leading to apoptosis. Eugenol promotes the apoptosis of MDSCs the intrinsic pathway.

摘要

研究丁香酚对CD11bGr1髓源性抑制细胞（MDSCs）的作用及潜在分子机制。采用MTT法检测丁香酚对永生化MDSC细胞系MSC-2和小鼠腹腔巨噬细胞的抑制作用。运用流式细胞术检测丁香酚对MDSCs的促凋亡作用。通过蛋白质免疫印迹法检测凋亡相关蛋白的表达水平。丁香酚对MDSCs具有剂量依赖性的选择性抑制作用，可激活内源性凋亡途径，导致细胞凋亡。丁香酚通过内源性途径促进MDSCs凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/e5d90a3f3f18/c7ra13499a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/62a586b01986/c7ra13499a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/99c614f4b0fa/c7ra13499a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/246d66b9906c/c7ra13499a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/d643b7db13b2/c7ra13499a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/e5d90a3f3f18/c7ra13499a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/62a586b01986/c7ra13499a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/99c614f4b0fa/c7ra13499a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/246d66b9906c/c7ra13499a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/d643b7db13b2/c7ra13499a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b0/9077712/e5d90a3f3f18/c7ra13499a-f5.jpg

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Oncotarget. 2017 May 5;8(34):56296-56310. doi: 10.18632/oncotarget.17626. eCollection 2017 Aug 22.
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Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts.丁香（ Eugenia caryophyllata）精油对人皮肤成纤维细胞的抗炎活性
Pharm Biol. 2017 Dec;55(1):1619-1622. doi: 10.1080/13880209.2017.1314513.
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In Vitro Incorporation of Radioiodinated Eugenol on Adenocarcinoma Cell Lines (Caco2, MCF7, and PC3).
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Cancer Biother Radiopharm. 2017 Apr;32(3):75-81. doi: 10.1089/cbr.2017.2181. Epub 2017 Mar 30.
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Eugenol and Its Role in Chronic Diseases.丁香酚及其在慢性病中的作用。
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Oxidized Low-Density Lipoprotein Induces Apoptosis in Cultured Neonatal Rat Cardiomyocytes by Modulating the TLR4/NF-κB Pathway.氧化型低密度脂蛋白通过调节TLR4/NF-κB信号通路诱导培养的新生大鼠心肌细胞凋亡。
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Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro.丁香酚的凋亡效应涉及G2/M期阻滞，同时伴有线粒体损伤以及对体外癌细胞的致染色体断裂效应。
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