Dervis Emine, Yurt Kilcar Ayfer, Medine Emin Ilker, Tekin Volkan, Cetkin Buse, Uygur Emre, Muftuler Fazilet Zumrut Biber
1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
2 Department of Chemistry, Faculty of Science, Ege University , Izmir, Turkey .
Cancer Biother Radiopharm. 2017 Apr;32(3):75-81. doi: 10.1089/cbr.2017.2181. Epub 2017 Mar 30.
Recently, the synthesis of radiolabeled plant origin compounds has been increased due to their high uptake on some cancer cell lines. Eugenol (EUG), a phenolic natural compound in the essential oils of different spices such as Syzygium aromaticum (clove), Pimenta racemosa (bay leaves), and Cinnamomum verum (cinnamon leaf), has been exploited for various medicinal applications. EUG has antiviral, antioxidant, and anti-inflammatory functions and several anticancer properties. The objective of this article is to synthesize radioiodinated (I) EUG and investigate its effect on Caco2, MCF7, and PC3 adenocarcinoma cell lines. It is observed that radioiodinated EUG would have potential on therapy and imaging due to its notable uptakes in studied cells.
最近，由于放射性标记的植物源化合物在某些癌细胞系中的高摄取率，其合成量有所增加。丁香酚（EUG）是一种酚类天然化合物，存在于不同香料的精油中，如丁香（丁香）、多香果（月桂叶）和锡兰肉桂（肉桂叶），已被用于各种医学应用。EUG具有抗病毒、抗氧化和抗炎功能以及多种抗癌特性。本文的目的是合成放射性碘化（I）EUG，并研究其对Caco2、MCF7和PC3腺癌细胞系的影响。据观察，放射性碘化EUG由于在研究的细胞中有显著摄取，在治疗和成像方面具有潜力。
