靶向特应性皮炎的皮肤共生菌群：“新希望”还是“凝固酶阴性葡萄球菌的侵袭”？
Targeting the cutaneous microbiota in atopic dermatitis: 'A new hope' or 'attack of the CoNS'?
机构信息
Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
出版信息
Clin Transl Med. 2022 May;12(5):e865. doi: 10.1002/ctm2.865.
Abstract
Although evidence showing that Staphylococcus aureus (S. aureus) is directly causative of atopic dermatitis (AD) is still lacking, there is evidence that S. aureus abundance is associated with disease flares and therapeutic responses. Patients receiving ATx201 OINTMENT 2% twice-daily had a significant reduction in the abundance of S. aureus and increasing Shannon diversity of skin microbiome compared to vehicle after seven days. A small molecule with a narrow-spectrum effect, especially on S. aureus, might be an attractive alternative for the treatment of AD.
摘要
虽然目前尚无证据表明金黄色葡萄球菌（S. aureus）直接导致特应性皮炎（AD），但有证据表明金黄色葡萄球菌丰度与疾病加重和治疗反应有关。与赋形剂相比，接受 ATx201 软膏 2%每天两次治疗的患者在 7 天后金黄色葡萄球菌丰度显著降低，皮肤微生物组的香农多样性增加。一种具有窄谱作用的小分子，特别是对金黄色葡萄球菌，可能是治疗 AD 的一种有吸引力的替代方法。
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本文引用的文献
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