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1
Targeting the cutaneous microbiota in atopic dermatitis: 'A new hope' or 'attack of the CoNS'?靶向特应性皮炎的皮肤共生菌群：“新希望”还是“凝固酶阴性葡萄球菌的侵袭”？
Clin Transl Med. 2022 May;12(5):e865. doi: 10.1002/ctm2.865.
2
Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial.局部用尼克罗米（ATx201）可减少特应性皮炎患者金黄色葡萄球菌定植，并增加皮肤微生物组的香农多样性：一项随机、双盲、安慰剂对照的 2 期临床试验。
Clin Transl Med. 2022 May;12(5):e790. doi: 10.1002/ctm2.790.
3
Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review.皮肤微生物组失调与金黄色葡萄球菌在成人和儿童特应性皮炎中的作用：叙述性综述。
J Eur Acad Dermatol Venereol. 2023 Jun;37 Suppl 5:3-17. doi: 10.1111/jdv.19125.
4
Distinct Skin Microbiota Imbalance and Responses to Clinical Treatment in Children With Atopic Dermatitis.特应性皮炎患儿不同的皮肤微生物群失衡及对临床治疗的反应
Front Cell Infect Microbiol. 2020 Jul 3;10:336. doi: 10.3389/fcimb.2020.00336. eCollection 2020.
5
Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis: Analysis of microbial diversity in ECZTRA 1, a randomized controlled trial.曲罗芦单抗治疗可通过增加中度至重度特应性皮炎成人患者的微生物多样性来改善皮肤微生物群：一项随机对照试验（ECZTRA 1）中的微生物多样性分析。
J Am Acad Dermatol. 2023 Apr;88(4):816-823. doi: 10.1016/j.jaad.2022.11.047. Epub 2022 Dec 5.
6
Apple cider vinegar soaks do not alter the skin bacterial microbiome in atopic dermatitis.苹果醋浸泡并不能改变特应性皮炎患者的皮肤细菌微生物组。
PLoS One. 2021 Jun 2;16(6):e0252272. doi: 10.1371/journal.pone.0252272. eCollection 2021.
7
Skin dysbiosis in the microbiome in atopic dermatitis is site-specific and involves bacteria, fungus and virus.特应性皮炎的微生物组皮肤微生态失调具有特定部位特征，涉及细菌、真菌和病毒。
BMC Microbiol. 2021 Sep 23;21(1):256. doi: 10.1186/s12866-021-02302-2.
8
Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort.在MPAACH儿科队列中，金黄色葡萄球菌皮肤分离株的生物膜形成倾向与特应性皮炎严重程度增加和屏障功能障碍有关。
Allergy. 2021 Jan;76(1):302-313. doi: 10.1111/all.14489. Epub 2020 Aug 9.
9
Biotherapeutic Approaches in Atopic Dermatitis.特应性皮炎的生物治疗方法。
Biotechnol J. 2020 Oct;15(10):e1900322. doi: 10.1002/biot.201900322. Epub 2020 Apr 6.
10
Cheek Microbial Communities Vary in Young Children with Atopic Dermatitis in China.中国特应性皮炎患儿的脸颊微生物群落存在差异。
Dermatology. 2020;236(2):160-169. doi: 10.1159/000502469. Epub 2019 Sep 25.

引用本文的文献

1
Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis.微生物衍生的抗菌肽作为特应性皮炎的潜在治疗方法。
Front Immunol. 2023 Jan 25;14:1125635. doi: 10.3389/fimmu.2023.1125635. eCollection 2023.
2
Skin Commensal Bacteria Modulates the Immune Balance of Mice to Alleviate Atopic Dermatitis-Induced Damage.皮肤共生细菌调节小鼠免疫平衡以减轻特应性皮炎诱导的损伤。
Evid Based Complement Alternat Med. 2022 Sep 17;2022:4731675. doi: 10.1155/2022/4731675. eCollection 2022.

本文引用的文献

1
Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial.局部用尼克罗米（ATx201）可减少特应性皮炎患者金黄色葡萄球菌定植，并增加皮肤微生物组的香农多样性：一项随机、双盲、安慰剂对照的 2 期临床试验。
Clin Transl Med. 2022 May;12(5):e790. doi: 10.1002/ctm2.790.
2
Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis.表皮葡萄球菌蛋白酶 EcpA 可能是特应性皮炎皮肤微生物组的有害成分。
J Allergy Clin Immunol. 2021 Mar;147(3):955-966.e16. doi: 10.1016/j.jaci.2020.06.024. Epub 2020 Jul 4.
3
The microbiome in patients with atopic dermatitis.特应性皮炎患者的微生物组。
J Allergy Clin Immunol. 2019 Jan;143(1):26-35. doi: 10.1016/j.jaci.2018.11.015. Epub 2018 Nov 23.
4
Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing.凝固酶阴性葡萄球菌菌株通过阻断群体感应来预防金黄色葡萄球菌定植和皮肤感染。
Cell Host Microbe. 2017 Dec 13;22(6):746-756.e5. doi: 10.1016/j.chom.2017.11.001. Epub 2017 Nov 30.
5
Antimicrobials from human skin commensal bacteria protect against and are deficient in atopic dermatitis.来自人体皮肤共生菌的抗菌物质可预防特应性皮炎，且特应性皮炎患者体内这些抗菌物质不足。
Sci Transl Med. 2017 Feb 22;9(378). doi: 10.1126/scitranslmed.aah4680.
6
Human commensals producing a novel antibiotic impair pathogen colonization.人类共生菌产生新型抗生素可破坏病原体定植。
Nature. 2016 Jul 28;535(7613):511-6. doi: 10.1038/nature18634.
7
Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis.特应性皮炎患者金黄色葡萄球菌定植的流行率和可能性：系统评价和荟萃分析。
Br J Dermatol. 2016 Oct;175(4):687-95. doi: 10.1111/bjd.14566. Epub 2016 Jul 5.
8
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.微生物群落失调与金黄色葡萄球菌定植引发特应性皮炎炎症
Immunity. 2015 Apr 21;42(4):756-66. doi: 10.1016/j.immuni.2015.03.014.
9
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis.与特应性皮炎儿童疾病发作和治疗相关的皮肤微生物组的时间推移。
Genome Res. 2012 May;22(5):850-9. doi: 10.1101/gr.131029.111. Epub 2012 Feb 6.
10
Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization.表皮葡萄球菌 Esp 抑制金黄色葡萄球菌生物膜的形成和鼻腔定植。
Nature. 2010 May 20;465(7296):346-9. doi: 10.1038/nature09074.

靶向特应性皮炎的皮肤共生菌群：“新希望”还是“凝固酶阴性葡萄球菌的侵袭”？

Targeting the cutaneous microbiota in atopic dermatitis: 'A new hope' or 'attack of the CoNS'?

机构信息

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

出版信息

Clin Transl Med. 2022 May;12(5):e865. doi: 10.1002/ctm2.865.

DOI:10.1002/ctm2.865
PMID:35542966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9091992/
Abstract

Although evidence showing that Staphylococcus aureus (S. aureus) is directly causative of atopic dermatitis (AD) is still lacking, there is evidence that S. aureus abundance is associated with disease flares and therapeutic responses. Patients receiving ATx201 OINTMENT 2% twice-daily had a significant reduction in the abundance of S. aureus and increasing Shannon diversity of skin microbiome compared to vehicle after seven days. A small molecule with a narrow-spectrum effect, especially on S. aureus, might be an attractive alternative for the treatment of AD.

摘要

虽然目前尚无证据表明金黄色葡萄球菌（S. aureus）直接导致特应性皮炎（AD），但有证据表明金黄色葡萄球菌丰度与疾病加重和治疗反应有关。与赋形剂相比，接受 ATx201 软膏 2%每天两次治疗的患者在 7 天后金黄色葡萄球菌丰度显著降低，皮肤微生物组的香农多样性增加。一种具有窄谱作用的小分子，特别是对金黄色葡萄球菌，可能是治疗 AD 的一种有吸引力的替代方法。