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特应性皮炎患儿不同的皮肤微生物群失衡及对临床治疗的反应

Distinct Skin Microbiota Imbalance and Responses to Clinical Treatment in Children With Atopic Dermatitis.

作者信息

Liu Ying, Wang Shan, Dai Wenkui, Liang Yuan, Shen Chunping, Li Yunzhu, Jiao Lei, Bian Yawei, Gao Zhan, Li Yinhu, Li Dongfang, Li Shuaicheng, Blaser Martin J, Tang Yi-Wei, Ma Lin

机构信息

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Department of Computer Science, City University of Hong Kong, Hong Kong, China.

出版信息

Front Cell Infect Microbiol. 2020 Jul 3;10:336. doi: 10.3389/fcimb.2020.00336. eCollection 2020.

DOI:10.3389/fcimb.2020.00336
PMID:32719752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7350538/
Abstract

Atopic dermatitis (AD) is a common cutaneous disease, associated with imbalances in the skin microbiota. To explore the characteristics of the cutaneous microbiota and its dynamic changes during clinical treatment. Cutaneous swab samples were collected from 51 AD patients before treatment, and 40 AD patients remained after a 2-week treatment with mometasone and mupirocin. AD patients exhibited significant enrichments of and as well as obvious reductions of and . Based on the proportion of , the AD patients were further classified into predominant group (AD.S) and non-dominant (AD.ND) group. The AD.S group exhibited lower skin microbial diversity and higher atopic dermatitis (SCORAD) index. In the AD.S group, the cutaneous microbial diversity significantly increased from 2.9 ± 0.8 to 3.7 ± 1.0, while the relative abundance of decreased from 42.5 ± 20.7 to 10.3 ± 28.4 after treatment. In contrast, no significant skin microbiota changes were detected in the AD.ND group. AD patients with predominant had higher disease severity and lower microbiota diversity compared to patients in the AD.ND group. Mometasone and mupirocin therapy had significant effects on skin microbiota in AD.S patients, but had a paradoxical response in the AD.ND patients.

摘要

特应性皮炎（AD）是一种常见的皮肤病，与皮肤微生物群失衡有关。为了探究皮肤微生物群的特征及其在临床治疗期间的动态变化，在治疗前从51例AD患者中采集皮肤拭子样本，在使用莫米松和莫匹罗星进行2周治疗后，仍有40例AD患者。AD患者表现出 和 的显著富集以及 和 的明显减少。基于 的比例，AD患者进一步分为优势组（AD.S）和非优势组（AD.ND）。AD.S组表现出较低的皮肤微生物多样性和较高的特应性皮炎（SCORAD）指数。在AD.S组中，皮肤微生物多样性从2.9±0.8显著增加到3.7±1.0，而治疗后 的相对丰度从42.5±20.7降至10.3±28.4。相比之下，在AD.ND组中未检测到明显的皮肤微生物群变化。与AD.ND组患者相比，以 为主的AD患者疾病严重程度更高，微生物群多样性更低。莫米松和莫匹罗星治疗对AD.S患者的皮肤微生物群有显著影响，但在AD.ND患者中产生了矛盾的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/cf929144db7b/fcimb-10-00336-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/e919ac417dbf/fcimb-10-00336-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/5fe21436740b/fcimb-10-00336-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/e543aab58f46/fcimb-10-00336-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/3f852263c281/fcimb-10-00336-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/cf929144db7b/fcimb-10-00336-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/e919ac417dbf/fcimb-10-00336-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/5fe21436740b/fcimb-10-00336-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/e543aab58f46/fcimb-10-00336-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/3f852263c281/fcimb-10-00336-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e9/7350538/cf929144db7b/fcimb-10-00336-g0005.jpg

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