International Medicana Hospital, Department of Medical Oncology, Izmir, 35170, Turkey.
Mozaik Hospital, Department of Radiology, Hatay, 31070, Turkey.
Future Oncol. 2022 Jun;18(20):2489-2498. doi: 10.2217/fon-2022-0155. Epub 2022 May 11.
The importance of sarcopenic obesity (SO) in malignancy has recently been recognized. The authors aimed to investigate the clinical and body composition data of early-stage breast cancer (BC) patients by focusing on the components of metabolic syndrome (MetS) and SO. In this cross-sectional study with early-stage BC patients, the clinical and laboratory results were evaluated for diagnosing MetS. Bioimpedance analysis and muscle radiation attenuation (Hounsfield unit average calculation [HUAC]) using acquired computed tomography images were used to assess SO. The age at diagnosis, BMI, visceral fat ratio, hemoglobin A1c and CEA levels in patients with MetS were significantly higher (p < 0.05). A cutoff value of 39.4 Hounsfield units was significantly related to MetS with 76.5% sensitivity and 62% specificity. The mean HUAC in patients with MetS (36.9) was significantly lower than in those without MetS (41.4; p = 0.017). HUAC value predicted SO in early-stage BC patients with MetS.
肌肉减少性肥胖（SO）在恶性肿瘤中的重要性最近已得到认可。作者旨在通过关注代谢综合征（MetS）和 SO 的组成部分，研究早期乳腺癌（BC）患者的临床和身体成分数据。 在这项针对早期 BC 患者的横断面研究中，评估了临床和实验室结果以诊断 MetS。使用获得的 CT 图像进行生物阻抗分析和肌肉衰减（Hounsfield 单位平均计算[HUAC]），以评估 SO。患有 MetS 的患者的诊断年龄、BMI、内脏脂肪比、糖化血红蛋白和 CEA 水平明显更高（p<0.05）。39.4 Hounsfield 单位的截断值与 MetS 显著相关，具有 76.5%的敏感性和 62%的特异性。患有 MetS 的患者的平均 HUAC（36.9）明显低于无 MetS 的患者（41.4；p=0.017）。HUAC 值预测了患有 MetS 的早期 BC 患者的 SO。
