Department of Family Medicine, National Taiwan University, Yun-Lin Branch, Taiwan.
Obes Res Clin Pract. 2013 Jul-Aug;7(4):e301-7. doi: 10.1016/j.orcp.2012.02.003.
Obesity is a risk factor for metabolic syndrome (MetS). We aimed to investigate whether sarcopenic obesity (SO) was associated with MetS.
A total of 600 community-dwelling males and females aged 63.6 ± 10.1 years in Northern Taiwan were enrolled in this study. Sarcopenia was defined by the percentage of total skeletal mass (total skeletal muscle mass (kg)/weight (kg) x 100). Cut-offs were established at <37% in men and <27.6% in women using the bioelectrical impedance analysis (BIA) method. Obesity was defined as body mass index (BMI) ≥25 kg/m(2). MetS was defined by the consensus of National Cholesterol Education Program-Adult Treatment Panel III modified for Asians. The association between MetS and SO was examined using multivariate logistic regression analyses after controlling potential confounders.
The SO group demonstrated a higher risk for MetS (odds ratio [OR] 11.59 [95% confidence interval [CI] 6.72-19.98]) than the obese group (7.53 [4.01-14.14]) and sarcopenic group (1.98 [1.25-3.16]). The individual components including waist circumference, serum triglycerides, high-density lipoprotein cholesterol (HDL-C), and fasting serum glucose were independently associated with SO.
SO is a major risk factor for MetS. The BIA method and BMI can easily identify subjects at high risk for MetS. The underlying mechanism for the relationship between SO and MetS warrants further research.
肥胖是代谢综合征（MetS）的一个危险因素。我们旨在研究肌少症性肥胖（SO）是否与 MetS 相关。
本研究共纳入了台湾北部 600 名年龄为 63.6±10.1 岁的社区居住的男性和女性。肌少症定义为全身骨骼质量的百分比（全身骨骼肌质量（kg）/体重（kg）x100）。使用生物电阻抗分析（BIA）方法，男性的截断值<37%，女性的截断值<27.6%。肥胖定义为体质指数（BMI）≥25kg/m²。MetS 采用经亚洲人改良的国家胆固醇教育计划-成人治疗专家组 III 共识定义。在控制潜在混杂因素后，采用多变量逻辑回归分析检查 MetS 与 SO 之间的关联。
与肥胖组（7.53[4.01-14.14]）和肌少症组（1.98[1.25-3.16]）相比，SO 组发生 MetS 的风险更高（比值比[OR]11.59[95%置信区间[CI]6.72-19.98]）。腰围、血清甘油三酯、高密度脂蛋白胆固醇（HDL-C）和空腹血糖等个体成分与 SO 独立相关。
SO 是 MetS 的一个主要危险因素。BIA 方法和 BMI 可以很容易地识别出发生 MetS 风险较高的人群。SO 与 MetS 之间的关系的潜在机制需要进一步研究。
