体脂质量比低预示晚期非小细胞肺癌患者预后不良。
A Low Body Fat Mass Ratio Predicts Poor Prognosis in Patients with Advanced Non-Small Cell Lung Cancer.
机构信息
Department of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Department of Internal Medicine, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
出版信息
Nutr Cancer. 2022;74(9):3284-3291. doi: 10.1080/01635581.2022.2074064. Epub 2022 May 11.
PURPOSE
The aim of this study was to investigate the effect of the body fat mass ratio on survival and prognosis in advanced non-small-cell lung cancer patients.
METHODS
The study includes 200 patients who were diagnosed with advanced non-small-cell lung cancer between 2014 and 2018 and whose body fat mass percentage and body mass index (BMI) were determined using the Tanita Body Composition Analyzer during admission.
RESULTS
All patients had advanced incurable non-small-cell lung cancer (30% had locally advanced disease, 70% were stage IV). In the univariate and multivariate analyses, age, gender, histopathological type, smoking history, comorbidities, weight loss in the last six months and body mass index had no statistically significant effect on survival ( > 0.05). However, the performance status ( = 0.008), metastatic status ( = 0.003) and body fat mass ratio ( = 0.01) were found to have a significant effect on overall survival (OS): the median OS was 16.4 mo, in patients with the BFM ratio ≤ 22% and 29.2 mo, in those with > 22% ( = 0.01).
CONCLUSION
In this study, it was found that the body fat mass ratio was an important prognostic factor in patients with advanced non-small-cell lung cancer.
目的
本研究旨在探讨体脂肪质量比对晚期非小细胞肺癌患者生存和预后的影响。
方法
本研究纳入了 200 例 2014 年至 2018 年间诊断为晚期非小细胞肺癌且在入院时使用 Tanita 身体成分分析仪确定体脂肪百分比和体重指数（BMI）的患者。
结果
所有患者均患有晚期不可治愈的非小细胞肺癌（30%为局部晚期疾病，70%为 IV 期）。在单因素和多因素分析中，年龄、性别、组织病理学类型、吸烟史、合并症、过去六个月的体重减轻和 BMI 对生存无统计学意义（ > 0.05）。然而，表现状态（ = 0.008）、转移状态（ = 0.003）和体脂肪质量比（ = 0.01）对总生存期（OS）有显著影响：BFM 比≤22%的患者中位 OS 为 16.4 个月，而 BFM 比>22%的患者中位 OS 为 29.2 个月（ = 0.01）。
结论
在这项研究中，发现体脂肪质量比是晚期非小细胞肺癌患者的一个重要预后因素。
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