Lobachevskiĭ P N, Mishchonova V B
Radiobiologiia. 1987 Mar-Apr;27(2):195-9.
A study was made of the influence of rad mutation, leading to radiosensitivity increase, on the effect of additional growth in diploid Saccharomyces cerevisiae yeast exposed to gamma-radiation. The most radiosensitive mutants of this series, rad52/rad52 and rad54/rad54, did not virtually vary from the wild type cells in the value of the additional growth effect. Some other mutants, for instance, rad53/rad53 and rad55/rad55, exhibited a significantly lesser effect of additional growth. It was shown that the effect of additional growth did not depend upon the rate of rapid and slow postirradiation recovery of the wild type cells. The results of the studies prompt the conclusion that the processes responsible for the additional growth effect and those responsible for recovery of cells from radiation damages are mutually independent.
研究了导致辐射敏感性增加的rad突变对经γ辐射处理的二倍体酿酒酵母额外生长效应的影响。该系列中最具辐射敏感性的突变体rad52/rad52和rad54/rad54，其额外生长效应的值与野生型细胞几乎没有差异。其他一些突变体，例如rad53/rad53和rad55/rad55，表现出明显较小的额外生长效应。结果表明，额外生长效应并不取决于野生型细胞辐照后快速和缓慢恢复的速率。这些研究结果促使得出这样的结论：导致额外生长效应的过程与负责细胞从辐射损伤中恢复的过程相互独立。
