Han Lin, Su Xiu-Zhen, Zhang Zhong-Yuan, Liu Ying, Wei Zhong-Xiang, Zhang Qing-Lan, Zhang Jun-Ping, Wang Chen-Xi, Su Quan-de
College of Acupuncture-Moxibustion and Tuina, Shandong University of TCM, Jinan 250355,China.
College of Acupuncture-Moxibustion and Tuina, Shandong University of TCM, Jinan 250355,China; Department of Acupuncture and Moxibustion, Weifang Hospital of TCM, Weifang 261041, Shandong Province.
Zhongguo Zhen Jiu. 2022 May 12;42(5):493-7. doi: 10.13703/j.0255-2930.20210605-0001.
To compare the curative effect of needling at Jiaji (EX-B 2) combined with western medication and western medication alone on motor dysfunction in patients with Parkinson's disease (PD) of liver and kidney deficiency.
A total of 98 patients with PD were randomly divided into an acupuncture and medication group (49 cases, 1 case dropped off) and a western medication group (49 cases,1 case was removed). The patients in the western medication group were given oral of levodopa and benserazide hydrochloride tablets, 125 mg each time, three times a day in the 1st week, and the dose was increased according to the needs of the patients' condition from the 2nd week until 250 mg each time, three times a day, for 16 consecutive weeks. On the basis of the same western medication treatment as the western medication group, needling was applied at Jiaji (EX-B 2) from C to L in the acupuncture and medication group, once a day, 20 times as a course of treatment, for 4 consecutive courses. The scores of unified Parkinson's disease rating scale (UPDRS-Ⅲ, UPDRS-Ⅳ), TCM symptoms score, and 39-item Parkinson's disease questionnaire (PDQ-39) score were evaluated before treatment, after treatment and during follow-up of 1 month after treatment, respectively. The safety of the two groups was compared.
After treatment and during follow-up, except the PDQ-39 score of the western medication group, the scores of UPDRS-Ⅲ, UPDRS-Ⅳ, TCM syndrome and PDQ-39 were lower than those before treatment in the two groups (<0.05), and the scores of above indexes in the acupuncture and medication group were lower than those of the western medication group (<0.05). The total incidence of adverse reactions in the acupuncture and medication group was 10.4% (5/48), which was lower than 29.2% (14/48) in the western medication group (<0.05).
needling at Jiaji (EX-B 2) combined with western medication could significantly improve the motor dysfunction and clinical symptoms, improve the quality of life and has high safety, and the efficacy is superior to western medication alone.
比较夹脊穴（EX-B 2）针刺联合西药与单纯西药治疗肝肾亏虚型帕金森病（PD）患者运动功能障碍的疗效。
将98例PD患者随机分为针药组（49例，脱落1例）和西药组（49例，剔除1例）。西药组患者口服左旋多巴和盐酸苄丝肼片，第1周每次125mg，每日3次，从第2周起根据病情需要增加剂量，直至每次250mg，每日3次，连续服用16周。针药组在与西药组相同西药治疗的基础上，针刺夹脊穴（EX-B 2），从C至L，每日1次，20次为1个疗程，连续治疗4个疗程。分别于治疗前、治疗后及治疗后1个月随访时评估统一帕金森病评定量表（UPDRS-Ⅲ、UPDRS-Ⅳ）评分、中医症状评分及帕金森病39项问卷（PDQ-39）评分。比较两组的安全性。
治疗后及随访期间，两组除西药组PDQ-39评分外，UPDRS-Ⅲ、UPDRS-Ⅳ、中医证候及PDQ-39评分均低于治疗前（P<0.05），且针药组上述指标评分低于西药组（P<0.05）。针药组不良反应总发生率为10.4%（5/48），低于西药组的29.2%（14/48）（P<0.05）。
夹脊穴（EX-B 2）针刺联合西药能显著改善运动功能障碍和临床症状，提高生活质量，安全性高，疗效优于单纯西药。
