IRE1α 在抗肿瘤免疫中的激活和功能的新见解。
New insights into IRE1α activation and function in anti-tumor immunity.
机构信息
Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
CancerCare Manitoba Research Institute, Winnipeg, Manitoba, Canada.
出版信息
J Cell Biol. 2022 Jun 6;221(6). doi: 10.1083/jcb.202205019. Epub 2022 May 11.
Abstract
Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.
摘要
罗格、戈尔曼和萨马利强调了古特曼及其同事的一项研究（2022 年，《细胞生物学杂志》，https://doi.org/10.1083/jcb.202111068），该研究表明，进入内质网的外源性抗原肽可以激活内质网应激传感器 IRE1α，从而减弱树突状细胞的交叉呈递。
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