Barlatay Joaquin Miguel Gonzalez, Boza Carla Pagano, Basso Tomaz Ortiz, Benavente Mercedes, Hernández-Gauna Guillermo Vicente, Premoli Eduardo Jorge
Division of Orbital and Ophthalmic Plastic Surgery, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Arq Bras Oftalmol. 2023 Oct 13;86(5):e20230063. doi: 10.5935/0004-2749.20230063. eCollection 2023.
Peribulbar injection of triamcinolone is an alternative treatment for thyroid eye disease; however the safety profile of this therapeutic option remains controversial. The aim of this study was to describe the occurrence of local and systemic adverse effects after peribulbar injection of triamcinolone in patients with thyroid eye disease.
This was a retrospective case series. Medical records of patients with thyroid eye disease treated with peribulbar injections of triamcinolone at a single academic institution between 2007 and 2019 were analyzed. Local and systemic complications were documented.
A total of 123 patients were treated. Only 11 patients (8.9%) developed local complications. The most frequent complication was the presence of superficial eyelid ecchymosis (nine patients; 7.3%). Notably, systemic complications (hyperglycemic and suprarenal inhibition after stop treatment) occurred in two patients (1.6%). All complications were transient, and the patients did not have any long-term sequelae.
Peribulbar injection of triamcinolone for the treatment of thyroid eye disease is linked to a very low rate of local or systemic complications. Prospective studies are warranted to delve into this topic.
球周注射曲安奈德是甲状腺眼病的一种替代治疗方法；然而，这种治疗选择的安全性仍存在争议。本研究的目的是描述甲状腺眼病患者球周注射曲安奈德后局部和全身不良反应的发生情况。
这是一项回顾性病例系列研究。分析了2007年至2019年间在单一学术机构接受球周注射曲安奈德治疗的甲状腺眼病患者的病历。记录局部和全身并发症。
共治疗123例患者。仅11例患者（8.9%）出现局部并发症。最常见的并发症是眼睑浅表瘀斑（9例患者；7.3%）。值得注意的是，2例患者（1.6%）出现全身并发症（停药后高血糖和肾上腺抑制）。所有并发症均为短暂性，患者无任何长期后遗症。
球周注射曲安奈德治疗甲状腺眼病与极低的局部或全身并发症发生率相关。有必要进行前瞻性研究以深入探讨这一主题。
