Bedwell A E, Elson C J, Hinton C E
Scand J Immunol. 1987 Apr;25(4):393-8. doi: 10.1111/j.1365-3083.1987.tb02205.x.
Evidence is presented that the development of arthritis induced in mice by 2,6,10,14-tetramethylpentadecane (pristane) involves the immune response. Mice irradiated (500 rad) before injection of pristane failed to develop arthritis. By contrast, irradiated mice given lymphoid cells from normal donors and challenged with pristane developed arthritis. Other experiments showed that lymphoid cells from irradiated mice given pristane suppressed the development of arthritis in recipients challenged with pristane. Finally, the incidence of arthritis was significantly higher in CBA/Igb mice given pristane than in the allotypic congenic strain CBA/H, suggesting that a gene linked to the heavy chain immunoglobulin locus controls the development of arthritis.
有证据表明，2,6,10,14-四甲基十五烷（ pristane ）诱导小鼠发生关节炎的过程涉及免疫反应。在注射pristane之前接受照射（500拉德）的小鼠未发生关节炎。相比之下，接受正常供体淋巴细胞照射并注射pristane的小鼠发生了关节炎。其他实验表明，注射pristane的受照射小鼠的淋巴细胞抑制了接受pristane攻击的受体小鼠的关节炎发展。最后，注射pristane的CBA/Igb小鼠的关节炎发病率明显高于同种异型同基因品系CBA/H，这表明与重链免疫球蛋白基因座相关的一个基因控制着关节炎的发展。
