McLean L, Winrow V, Blake D
Clinical Research Centre, Harrow, London, UK.
J Exp Pathol (Oxford). 1990 Apr;71(2):295-303.
'Stress Proteins in Inflammation' provided a forum for the discussion of topical issues in this rapidly moving field. The mycobacterial 65 kDa stress proteins play a key role in certain animal models of inflammatory arthritis. However, the impression emerging is that the mechanism probably involves more than a simple cross-reaction between mycobacterial SP65 and either the host SP65 or a cartilage antigen, and that evidence for a primary role in human rheumatoid arthritis is lacking. A realistic role for immune responses against stress proteins might be the amplification or perpetuation of inflammation. If so, this is unlikely to be limited to arthritis.
《炎症中的应激蛋白》为讨论这个快速发展领域的热点问题提供了一个平台。分枝杆菌65 kDa应激蛋白在某些炎性关节炎动物模型中起关键作用。然而，新出现的印象是，其机制可能不仅仅涉及分枝杆菌SP65与宿主SP65或软骨抗原之间的简单交叉反应，而且缺乏其在人类类风湿性关节炎中起主要作用的证据。针对应激蛋白的免疫反应的一个实际作用可能是炎症的放大或持续存在。如果是这样，这不太可能仅限于关节炎。
