Cancer Research Institute, Central South University, Changsha 410078.
Departments of Respiratory and Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen Guangdong 518036, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Mar 28;47(3):358-363. doi: 10.11817/j.issn.1672-7347.2022.210275.
B lymphocyte is an important component of the human immune system and it has a role in the process of the body's specific immunity. In recent years, the research on B cells and tumor immune escape has rapidly progressed. Studies have shown that different types of B cells play different roles in tumor microenvironment through a variety of mechanisms. B cells in the tertiary lymphatic structure promote anti-tumor immunity, while regulatory B cells promote tumor immune escape. Antibody drugs targeting B cells are a promising direction for tumor immunotherapy.
B 淋巴细胞是人体免疫系统的重要组成部分，在机体特异性免疫过程中发挥着重要作用。近年来，B 细胞与肿瘤免疫逃逸的研究进展迅速。研究表明，不同类型的 B 细胞通过多种机制在肿瘤微环境中发挥不同作用，三级淋巴结构中的 B 细胞促进抗肿瘤免疫，而调节性 B 细胞则促进肿瘤免疫逃逸。靶向 B 细胞的抗体药物是肿瘤免疫治疗的一个有前景的方向。
