高迁移率族蛋白 B1 在癌症中的作用。
Role of high-mobility group box 1 in cancer.
机构信息
Second Department of Internal Medicine, People's Hospital of Guandu District, Kunming 650200.
Department of Clinical Laboratory, Yunan Cancer Hospital/Third Affiliated Hospital of Kunming Medical University, Kunming 650118.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Apr 28;47(4):505-511. doi: 10.11817/j.issn.1672-7347.2022.210679.
High-mobility group box 1 (HMGB1) is a non-histone nuclear protein in most eukaryocytes. Inside the nucleus, HMGB1 plays an important role in several DNA events such as DNA repair, transcription, telomere maintenance, and genome stability. While outside the nucleus, it fulfils more complicated functions, including promoting cell proliferation, inflammation, angiogenesis, immune tolerance and immune escape, which may play a pro-tumoral role.Meanwhile, HMGB1 acts as an anti-tumoral protein by regulating immune cell recruitment and inducing immunogenic cell death (ICD) during the carcinogenesis process. Therefore, abnormal expression of HMGB1 is associated with oncogenesis, development, and metastasis of cancer, which may play a dual role of pro-tumor and anti-tumor.
高迁移率族蛋白 B1（HMGB1）是大多数真核细胞中的非组蛋白核蛋白。在核内，HMGB1 在几种 DNA 事件中发挥重要作用，如 DNA 修复、转录、端粒维持和基因组稳定性。而在核外，它发挥着更复杂的功能，包括促进细胞增殖、炎症、血管生成、免疫耐受和免疫逃逸，这可能发挥促肿瘤作用。同时，HMGB1 在致癌过程中通过调节免疫细胞募集和诱导免疫原性细胞死亡（ICD）发挥抗肿瘤蛋白的作用。因此，HMGB1 的异常表达与癌症的发生、发展和转移有关，可能发挥促肿瘤和抗肿瘤的双重作用。
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