Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Liaoning Vica Agriculture and Animal Husbandry Ecological Food Co. Ltd, Liaoning, China.
Anim Genet. 2022 Aug;53(4):510-512. doi: 10.1111/age.13209. Epub 2022 May 11.
Litter traits are important in the development of production and economic profits of pigs. The object of this study was to perform genome-wide association studies (GWASs) for the total number born (TNB), number born alive (NBA) and number born healthy (NBH) traits in a Yorkshire population. By mixed model, we conducted GWASs with gcta software, and in total identified 3, 7 and 12 significant SNPs associated with TNB, NBA and NBH respectively: one on Sus scrofa chromosome (SSC) 2 (p = 7.03 × 10 ), one on SSC4 (p = 8.53 × 10 ), two on SSC 6 (p = 9.27 × 10 to 9.64 × 10 ), nine on SSC 8 (p = 1.53 × 10 to 8.52 × 10 ), four on SSC 14 (p = 2.17 × 10 to 6.79 × 10 ), and one on SSC 15 (p = 9.30 × 10 ). We screened for flanking regions ±1 Mb nearby or within the significant SNPs, and found 203 candidate genes, including 53 for TNB, 71 for NBA and 112 for NBH. In conclusion, our findings show the significant SNPs with candidate genes for the TNB, NBA and NBH traits in Yorkshire pigs.
litter 特性在猪的生产和经济利润的发展中很重要。本研究的目的是对约克夏猪的总产仔数（TNB）、产活仔数（NBA）和产健康仔数（NBH）进行全基因组关联研究（GWAS）。通过混合模型，我们使用 gcta 软件进行了 GWAS，总共鉴定出与 TNB、NBA 和 NBH 相关的 3、7 和 12 个显著 SNP：一个位于Sus scrofa 染色体（SSC）2 上（p = 7.03×10 -8 ），一个位于 SSC4 上（p = 8.53×10 -8 ），两个位于 SSC 6 上（p = 9.27×10 -8 至 9.64×10 -8 ），九个位于 SSC 8 上（p = 1.53×10 -7 至 8.52×10 -7 ），四个位于 SSC 14 上（p = 2.17×10 -7 至 6.79×10 -7 ），一个位于 SSC 15 上（p = 9.30×10 -7 ）。我们筛选了附近或在显著 SNP 内 ±1 Mb 的侧翼区域，发现了 203 个候选基因，包括 53 个与 TNB 相关，71 个与 NBA 相关，112 个与 NBH 相关。总之，我们的研究结果表明，在约克夏猪中，TNB、NBA 和 NBH 性状的显著 SNP 与候选基因有关。
