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家族性渗出性玻璃体视网膜病变和早产儿视网膜病变患者的中心凹发育不良和光学组件特征。

Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity.

机构信息

Department of Ophthalmology, Linkou Chang Gung Memorial Hospital, No. 5, Fu-Hsin Rd., Taoyuan, 333, Taiwan.

College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.

出版信息

Sci Rep. 2022 May 11;12(1):7694. doi: 10.1038/s41598-022-11455-7.

Abstract

There has been limited research regarding the status of foveal hypoplasia and the characteristics of the optical components of the eye in patients with familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP). In this retrospective cohort study, patients were classified into five groups: patients with stage 1 and 2 FEVR (FEVR group), patients with ROP who received treatment (treated ROP group), patients with ROP who did not receive treatment (untreated ROP group), patients without ROP who had been born preterm (preterm group), and healthy patients who had been born at term (full-term group). Visual acuity, refractive error, characteristics of the optical components, and features of the fovea were compared. In total, 179 eyes from 100 patients were included. Patients in the FEVR group had the highest degrees of myopia (p < 0.001). The axial length of patients in the FEVR group was significantly longer than that of patients in the treated and untreated ROP, preterm, and full-term groups (p < 0.001, p < 0.001, p = 0.001, and p = 0.003, respectively). Patients in the FEVR group had a higher proportion of grade 4 foveal hypoplasia and thinner foveae than those in the other groups (p < 0.001). Patients with FEVR had significantly greater myopic change than patients with ROP; the significantly longer axial length of the FEVR group might be the reason for the greater myopic change and lesser macular thickness. Patients in the FEVR group had more foveal hypoplasia than those in the other groups.

摘要

对于家族性渗出性玻璃体视网膜病变(FEVR)和早产儿视网膜病变(ROP)患者的黄斑发育不良和眼部光学部件的特征,相关研究较少。在这项回顾性队列研究中,患者被分为五组:1 期和 2 期 FEVR 患者(FEVR 组)、接受治疗的 ROP 患者(治疗 ROP 组)、未接受治疗的 ROP 患者(未治疗 ROP 组)、早产儿出生前无 ROP 但有早产儿视网膜病变(早产儿组)和足月出生的健康患者(足月组)。比较了视力、屈光不正、光学部件特征和黄斑特征。共纳入 100 例患者的 179 只眼。FEVR 组患者的近视程度最高(p<0.001)。FEVR 组患者的眼轴长度明显长于治疗和未治疗 ROP、早产儿和足月组患者(p<0.001,p<0.001,p=0.001,p=0.003)。FEVR 组患者的 4 级黄斑发育不良比例和黄斑厚度明显低于其他组(p<0.001)。FEVR 患者的近视变化明显大于 ROP 患者;FEVR 组明显较长的眼轴可能是近视变化较大和黄斑厚度较小的原因。FEVR 组患者的黄斑发育不良发生率高于其他组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b0/9095679/7ebdef25ab19/41598_2022_11455_Fig1_HTML.jpg

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