Wan Chuan, Yang Dongyan, Qin Xuan, Xue Ziyi, Guo Xiaochun, Hou Zhanfeng, Jiang Chenran, Yin Feng, Wang Rui, Li Zigang
State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China.
College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Org Biomol Chem. 2022 May 26;20(20):4105-4109. doi: 10.1039/d2ob00641c.
A biomimetic method has been established for the chemo-selective desulfurization of cysteinyl peptides and proteins in aqueous media. The derivatives of biocatalytic cofactors, flavins, were found to be efficient photosensitizers in a thiyl-radical-mediated desulfurization of Cys. The reaction was conducted in an ultrafast manner with both polypeptides and proteins.
已建立一种仿生方法，用于在水性介质中对半胱氨酰肽和蛋白质进行化学选择性脱硫。发现生物催化辅因子黄素的衍生物在硫自由基介导的半胱氨酸脱硫中是有效的光敏剂。该反应对多肽和蛋白质均以超快方式进行。
