评估血浆循环肿瘤人乳头瘤病毒（HPV）DNA 在确定 HPV 相关口咽癌治疗反应中的作用。
Assessing plasma circulating tumor human papillomavirus (HPV) DNA in determining treatment response in HPV-associated oropharyngeal cancer.
机构信息
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
出版信息
Head Neck. 2022 Aug;44(8):E25-E30. doi: 10.1002/hed.27081. Epub 2022 May 12.
BACKGROUND
Human papillomavirus (HPV)-mediated oropharyngeal squamous cell carcinoma is a subset of head and neck cancer with a unique mechanism of carcinogenesis. Local disease is treated definitively with a multimodal approach. Navigating recurrences can be challenging, as they are sometimes indiscernible from de novo primary malignancies. Identification of dynamic biomarkers that are specific to HPV-mediated disease may assist in disease monitoring. We present a 78-year-old man who developed a squamous cell carcinoma in the lung 7 years after completing definitive chemoradiation for his p16+ head and neck squamous cell carcinoma.
METHODS
A novel assay for plasma circulating tumor HPV DNA was employed and provided a tool for longitudinal disease monitoring during therapy.
CONCLUSION
We bring attention to a novel assay and highlight its potential for use in the treatment paradigm of HPV-mediated oropharyngeal carcinoma.
背景
人乳头瘤病毒（HPV）介导的口咽鳞状细胞癌是头颈部癌症的一个亚类，其具有独特的致癌机制。局部疾病采用多模式方法进行确定性治疗。由于复发与新发原发性恶性肿瘤有时难以区分，因此复发的治疗具有一定挑战性。识别特异性 HPV 介导疾病的动态生物标志物可能有助于疾病监测。我们介绍了一位 78 岁的男性，他在完成针对其 p16+头颈部鳞状细胞癌的确定性放化疗后 7 年，在肺部发展为鳞状细胞癌。
方法
采用新型血浆循环肿瘤 HPV DNA 检测方法，为治疗期间的纵向疾病监测提供了工具。
结论
我们关注一种新型检测方法，并强调其在 HPV 介导的口咽癌治疗模式中的潜在用途。
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