• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

加拿大多伦多药物检测服务中检出的新兴合成大麻素。

Emerging synthetic cannabinoids detected by a drug checking service in Toronto, Canada.

机构信息

Centre on Drug Policy Evaluation, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

出版信息

Clin Toxicol (Phila). 2022 Aug;60(8):979-984. doi: 10.1080/15563650.2022.2069575. Epub 2022 May 12.

DOI:10.1080/15563650.2022.2069575
PMID:35546568
Abstract

BACKGROUND

Toronto's Drug Checking Service (DCS) provides people who use drugs with information on the chemical composition of their substances and conducts real-time monitoring of the unregulated drug supply. Presented are first known data of three newly detected synthetic cannabinoids (SCs) in Toronto, Ontario.

METHODS

The present data are from samples analyzed between April and November 2020. Samples were collected at partnering harm reduction agencies in Toronto and analyzed using gas or liquid chromatography-mass spectrometry. An intake survey queried about the sample characteristics on submission, including expected drug(s).

RESULTS

Samples were analyzed between 1 April and 20 November 2020 ( = 19), which marks the period immediately following imposed COVID-19 border and movement restrictions in Canada. The newly detected, unexpected SCs were ACHMINACA ( = 15), AB-FUBINACA ( = 3), and 4-fluoro-MDMB-BUTINACA ( = 1). Fentanyl was expected in 74% ( = 14). Most SCs were detected in samples containing fentanyl or related analogues ( = 18; 95%), or benzodiazepine-related drugs (i.e., etizolam and flualprazolam) ( = 15; 79%).

CONCLUSIONS

This information can inform overdose prevention efforts and drug market monitoring of SCs in Toronto and regions served by the same drug trafficking routes. The detection of SCs during a period marked by COVID-19-related restrictions can contribute to efforts to identify global drug market trends during this time.

摘要

背景

多伦多药物检测服务(DCS)为使用者提供有关其物质化学成分的信息,并实时监测非管制药物供应情况。本文介绍了安大略省多伦多首次发现的三种新型合成大麻素(SCs)的已知数据。

方法

本数据来自 2020 年 4 月至 11 月分析的样本。样本在多伦多的合作减少伤害机构采集,并使用气相或液相色谱-质谱法进行分析。在提交样本时,摄入调查询问了样本特征,包括预期的药物。

结果

2020 年 4 月 1 日至 11 月 20 日期间分析了样本(n=19),这标志着加拿大实施 COVID-19 边境和流动限制后的时期。新发现的意外 SCs 为 ACHMINACA(n=15)、AB-FUBINACA(n=3)和 4-氟-MDMB-BUTINACA(n=1)。74%(n=14)的样本预期含有芬太尼。大多数 SCs 存在于含有芬太尼或相关类似物的样本中(n=18;95%),或苯二氮䓬类相关药物(即依托咪酯和氟拉卓伦)(n=15;79%)。

结论

这些信息可以为多伦多和通过相同贩毒途径提供服务的地区的 SC 过量预防工作和药物市场监测提供信息。在 COVID-19 相关限制期间检测到 SCs 可以为识别这一时期全球药物市场趋势做出贡献。

相似文献

1
Emerging synthetic cannabinoids detected by a drug checking service in Toronto, Canada.加拿大多伦多药物检测服务中检出的新兴合成大麻素。
Clin Toxicol (Phila). 2022 Aug;60(8):979-984. doi: 10.1080/15563650.2022.2069575. Epub 2022 May 12.
2
Diverse psychotropic substances detected in drug and drug administration equipment samples submitted to drug checking services in Toronto, Ontario, Canada, October 2019-April 2020.2019 年 10 月至 2020 年 4 月,在加拿大安大略省多伦多市的毒品检测服务机构提交的毒品和毒品管理设备样本中检测到多种精神药物。
Harm Reduct J. 2022 Jan 11;19(1):3. doi: 10.1186/s12954-021-00585-2.
3
Evaluating networked drug checking services in Toronto, Ontario: study protocol and rationale.评估安大略省多伦多的联网药物检测服务:研究方案和原理。
Harm Reduct J. 2020 Jan 28;17(1):9. doi: 10.1186/s12954-019-0336-0.
4
Xylazine detected in unregulated opioids and drug administration equipment in Toronto, Canada: clinical and social implications.在加拿大多伦多的未经监管的阿片类药物和药物管理设备中检测到苯环己哌啶:临床和社会影响。
Harm Reduct J. 2021 Oct 13;18(1):104. doi: 10.1186/s12954-021-00546-9.
5
Detection of synthetic cannabinoid adulteration in the unregulated drug supply in three Canadian settings.检测加拿大三个地区不受监管的毒品供应中的合成大麻素掺假情况。
Drug Alcohol Rev. 2021 May;40(4):580-585. doi: 10.1111/dar.13237. Epub 2020 Dec 22.
6
A new quantitative drug checking technology for harm reduction: Pilot study in Vancouver, Canada using paper spray mass spectrometry.一种新的用于减少伤害的定量药物检测技术:加拿大温哥华的试点研究,使用纸喷雾质谱法。
Drug Alcohol Rev. 2022 Feb;41(2):410-418. doi: 10.1111/dar.13370. Epub 2021 Aug 4.
7
Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply.药物检测服务作为临床实验室的监测工具:检测不受监管的芬太尼供应中的趋势。
Clin Biochem. 2023 Jan;111:11-16. doi: 10.1016/j.clinbiochem.2022.11.003. Epub 2022 Nov 12.
8
An outbreak of novel psychoactive substance benzodiazepines in the unregulated drug supply: Preliminary results from a community drug checking program using point-of-care and confirmatory methods.无管制毒品供应中新精神活性物质苯二氮䓬类药物的爆发:使用即时检测和确证方法的社区毒品检测计划的初步结果。
Int J Drug Policy. 2021 Jul;93:103169. doi: 10.1016/j.drugpo.2021.103169. Epub 2021 Feb 22.
9
Variability in the unregulated opioid market in the context of extreme rates of overdose.在过量用药率极高的情况下,无监管的阿片类药物市场的变异性。
Drug Alcohol Depend. 2022 Jun 1;235:109427. doi: 10.1016/j.drugalcdep.2022.109427. Epub 2022 Mar 26.
10
Drug checking use and interest among people who inject drugs in Toronto, Canada.在加拿大多伦多,药物检测在注射毒品者中的使用和兴趣。
Int J Drug Policy. 2022 Sep;107:103781. doi: 10.1016/j.drugpo.2022.103781. Epub 2022 Jul 5.

引用本文的文献

1
"It would really support the wider harm reduction agenda across the board": A qualitative study of the potential impacts of drug checking service delivery in Scotland.“这将真正全面支持更广泛的减少伤害议程”:苏格兰药物检测服务提供的潜在影响的定性研究。
PLoS One. 2023 Dec 14;18(12):e0292812. doi: 10.1371/journal.pone.0292812. eCollection 2023.
2
NPAideS: a drug-checking study among 3-methylmethcathinone (3-MMC) users.NPAideS:3-甲氧基甲基卡西酮(3-MMC)使用者的药物检测研究。
Harm Reduct J. 2023 Jul 28;20(1):96. doi: 10.1186/s12954-023-00836-4.
3
Interpol Review of Drug Analysis 2019-2022.
国际刑警组织2019 - 2022年毒品分析综述
Forensic Sci Int Synerg. 2023 Jan 5;6:100299. doi: 10.1016/j.fsisyn.2022.100299. eCollection 2023.