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加拿大多伦多药物检测服务中检出的新兴合成大麻素。

Emerging synthetic cannabinoids detected by a drug checking service in Toronto, Canada.

机构信息

Centre on Drug Policy Evaluation, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

出版信息

Clin Toxicol (Phila). 2022 Aug;60(8):979-984. doi: 10.1080/15563650.2022.2069575. Epub 2022 May 12.

Abstract

BACKGROUND

Toronto's Drug Checking Service (DCS) provides people who use drugs with information on the chemical composition of their substances and conducts real-time monitoring of the unregulated drug supply. Presented are first known data of three newly detected synthetic cannabinoids (SCs) in Toronto, Ontario.

METHODS

The present data are from samples analyzed between April and November 2020. Samples were collected at partnering harm reduction agencies in Toronto and analyzed using gas or liquid chromatography-mass spectrometry. An intake survey queried about the sample characteristics on submission, including expected drug(s).

RESULTS

Samples were analyzed between 1 April and 20 November 2020 ( = 19), which marks the period immediately following imposed COVID-19 border and movement restrictions in Canada. The newly detected, unexpected SCs were ACHMINACA ( = 15), AB-FUBINACA ( = 3), and 4-fluoro-MDMB-BUTINACA ( = 1). Fentanyl was expected in 74% ( = 14). Most SCs were detected in samples containing fentanyl or related analogues ( = 18; 95%), or benzodiazepine-related drugs (i.e., etizolam and flualprazolam) ( = 15; 79%).

CONCLUSIONS

This information can inform overdose prevention efforts and drug market monitoring of SCs in Toronto and regions served by the same drug trafficking routes. The detection of SCs during a period marked by COVID-19-related restrictions can contribute to efforts to identify global drug market trends during this time.

摘要

背景

多伦多药物检测服务(DCS)为使用者提供有关其物质化学成分的信息,并实时监测非管制药物供应情况。本文介绍了安大略省多伦多首次发现的三种新型合成大麻素(SCs)的已知数据。

方法

本数据来自 2020 年 4 月至 11 月分析的样本。样本在多伦多的合作减少伤害机构采集,并使用气相或液相色谱-质谱法进行分析。在提交样本时,摄入调查询问了样本特征,包括预期的药物。

结果

2020 年 4 月 1 日至 11 月 20 日期间分析了样本(n=19),这标志着加拿大实施 COVID-19 边境和流动限制后的时期。新发现的意外 SCs 为 ACHMINACA(n=15)、AB-FUBINACA(n=3)和 4-氟-MDMB-BUTINACA(n=1)。74%(n=14)的样本预期含有芬太尼。大多数 SCs 存在于含有芬太尼或相关类似物的样本中(n=18;95%),或苯二氮䓬类相关药物(即依托咪酯和氟拉卓伦)(n=15;79%)。

结论

这些信息可以为多伦多和通过相同贩毒途径提供服务的地区的 SC 过量预防工作和药物市场监测提供信息。在 COVID-19 相关限制期间检测到 SCs 可以为识别这一时期全球药物市场趋势做出贡献。

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