[脂质过氧化对大鼠脂肪细胞胰岛素受体的影响]
[Effect of lipid peroxidation on the insulin receptor in rat adipocytes].
作者信息
Ivanov V V, Stennikova M P, Pereboeva L A, Udintsev N A
出版信息
Ukr Biokhim Zh (1978). 1987 Mar-Apr;59(2):57-61.
PMID:3554677
Abstract
Lipid peroxidation is studied for its effect on insulin receptors in isolated rat adipocytes. The results suggest that addition of two peroxidants (3 mM cumene hydroperoxide and 0.2 mM Fe2+) leads to malondialdehyde accumulation and binding inhibition through insulin receptors quantity and affinity decrease.
摘要
研究了脂质过氧化对分离的大鼠脂肪细胞中胰岛素受体的影响。结果表明，添加两种过氧化物（3 mM 氢过氧化异丙苯和 0.2 mM Fe2+）会导致丙二醛积累，并通过胰岛素受体数量和亲和力的降低引起结合抑制。
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