Dayco John, Shahzad Shahzana, Tran Hanna, Ali Mohammed, Musa Mahmoud M, Alhusain Rashid, Awadelkarim Abdalaziz M, Mahabadi Navid, Raheem Shaheena, Urbanes Aris
Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, USA.
Internal Medicine, Wayne State University School of Medicine, Detroit, USA.
Cureus. 2022 Apr 10;14(4):e24014. doi: 10.7759/cureus.24014. eCollection 2022 Apr.
Antiphospholipid syndrome (APS) is a rare coagulopathic disorder diagnosed with a combination of clinical/imaging findings with specific antibody titer elevations over a period of 12 weeks. The following case report will discuss the unusual and challenging hospital course of a patient with extensive autosomal dominant polycystic kidney disease (ADPKD) being treated for a multi-drug resistant urinary tract infection (UTI). The patient later developed multiple deep vein thrombosis (DVT) and was found to have antiphospholipid syndrome. Warfarin, the anticoagulant of choice for antiphospholipid syndrome, has a higher likelihood of intracerebral hemorrhage than direct oral anticoagulants. This is particularly challenging since patients with autosomal dominant polycystic kidney disease have a higher propensity to develop intracranial aneurysms (ICA).
抗磷脂综合征（APS）是一种罕见的凝血功能障碍性疾病，通过临床/影像学检查结果与特定抗体滴度在12周内升高相结合来诊断。以下病例报告将讨论一名患有广泛常染色体显性多囊肾病（ADPKD）的患者在治疗耐多药尿路感染（UTI）时不寻常且具有挑战性的住院过程。该患者后来发生了多处深静脉血栓形成（DVT），并被发现患有抗磷脂综合征。华法林是抗磷脂综合征的首选抗凝剂，与直接口服抗凝剂相比，发生脑出血的可能性更高。这尤其具有挑战性，因为常染色体显性多囊肾病患者发生颅内动脉瘤（ICA）的倾向更高。
