Panneerselvam Karthikeyan, Mani Sathyamoorthy, Vasudevan Nandini, S Preethi, Krishnamoorthy Nedunchelian, Rk Pratibha, Sundar Subash
Pediatrics, SRM Medical College Hospital and Research Centre/SRM Institute of Science and Technology, Kattankulathur, IND.
Preventive Medicine, SRM Medical College Hospital and Research Centre/SRM Institute of Science and Technology, Kattankulathur, IND.
Cureus. 2022 Apr 7;14(4):e23938. doi: 10.7759/cureus.23938. eCollection 2022 Apr.
To assess the change in serum total calcium levels during light-emitting diode phototherapy treatment for jaundice in term neonates.
A prospective observational study was done on 104 term neonates with hyperbilirubinemia in a tertiary care center to investigate the effects of phototherapy using a light-emitting diode device. The total serum bilirubin along with total calcium levels was measured at the start and at the end of phototherapy. Additionally, all the newborns enrolled in the study were evaluated for hypocalcaemia-related symptoms such as jitteriness, irritability/excitability, lethargy, and convulsions.
A significant lowering of posttreatment total calcium level compared to that of pretreatment level (p<0.001) was found in our study. Hypocalcemia (serum calcium <8 mg/dL in term neonates) was found in 12.5% of the study subjects.
In the treatment of neonatal jaundice, similar to conventional blue and white light phototherapy, light-emitting diode phototherapy also has hypocalcemia as an adverse effect. We recommend monitoring these babies for hypocalcemia during light-emitting diode phototherapy.
评估足月儿黄疸接受发光二极管光疗期间血清总钙水平的变化。
在一家三级医疗中心对104例患有高胆红素血症的足月儿进行了一项前瞻性观察研究，以调查使用发光二极管设备进行光疗的效果。在光疗开始时和结束时测量血清总胆红素以及总钙水平。此外，对纳入研究的所有新生儿进行低钙血症相关症状评估，如震颤、易激惹/兴奋、嗜睡和惊厥。
我们的研究发现，与治疗前水平相比，治疗后总钙水平显著降低（p<0.001）。12.5%的研究对象出现低钙血症（足月儿血清钙<8mg/dL）。
在新生儿黄疸治疗中，与传统的蓝光和白光光疗一样，发光二极管光疗也有低钙血症这一不良反应。我们建议在发光二极管光疗期间对这些婴儿进行低钙血症监测。
