Alajaimi Ahmed, Altooq Noor, Chandran Nisha, Alderazi Yaser
College of Medicine & Medical Science, Arabian Gulf University, Manama, BHR.
Department of Pathology, Salmaniya Medical Complex, Manama, BHR.
Cureus. 2022 Apr 10;14(4):e24006. doi: 10.7759/cureus.24006. eCollection 2022 Apr.
Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Compared to parathyroid adenoma, parathyroid cancer is more likely to be associated with marked levels of serum parathyroid hormone (PTH) and hypercalcemia with severe clinical manifestations. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a rare variant of papillary thyroid cancer. Here, we report the case of a middle-aged woman who presented with multiple fractures and neck swelling. Neck ultrasound and fine-needle aspiration cytology revealed a provisional diagnosis of thyroid carcinoma. Parathyroid and bone scan were performed because of primary hyperparathyroidism and hypercalcemia and established the diagnosis of hyperfunctioning right-sided parathyroid tumor. Right parathyroidectomy and total thyroidectomy were performed, and the histopathological report confirmed the diagnosis of parathyroid carcinoma and NIFTP. The synchronic coexistence between parathyroid cancer and thyroid neoplasms is an extremely rare condition that prompted us to report this case.
甲状旁腺癌是原发性甲状旁腺功能亢进症的罕见病因。与甲状旁腺腺瘤相比，甲状旁腺癌更易与高水平的血清甲状旁腺激素（PTH）及高钙血症相关，且伴有严重的临床表现。具有乳头样核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）是甲状腺乳头状癌的一种罕见变体。在此，我们报告一例中年女性病例，该患者出现多处骨折及颈部肿胀。颈部超声和细针穿刺细胞学检查初步诊断为甲状腺癌。因原发性甲状旁腺功能亢进症和高钙血症进行了甲状旁腺和骨扫描，确诊为右侧甲状旁腺功能亢进性肿瘤。实施了右侧甲状旁腺切除术和全甲状腺切除术，组织病理学报告证实了甲状旁腺癌和NIFTP的诊断。甲状旁腺癌与甲状腺肿瘤的同步并存是一种极其罕见的情况，促使我们报告此病例。
