Hu Feng, Cheng Jianduan, Yu Yun, Wang Tao, Zhou Wei, Yu Chao, Zhu Lingjuan, Bao Huihui, Cheng Xiaoshu
Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang, China.
Front Physiol. 2022 Apr 25;13:857787. doi: 10.3389/fphys.2022.857787. eCollection 2022.
This prospective study examined the relationship between body mass index (BMI) and all-cause mortality in Chinese adults without morbid obesity. We prospectively examined the relationship between BMI and all-cause mortality in 12,608 Southern Chinese adults with age ≥35 years who participated in the National Key R&D Program from 2013-2014 to 2019-2020. Cox proportional hazards models were used to examine the association between BMI and all-cause mortality. The prevalence of being underweight, normal weight, overweight and having moderate obesity was 7.36%, 55.83%, 28.51% and 8.31%, respectively. A total of 683 (5.65%) deaths occurred during a median follow-up period of 5.61 years. The Cox proportional hazards models indicated that a continuous BMI level was negatively associated with all-cause mortality [adjusted-hazard ratio (HR) per 1 kg/m increase: 0.96, 95% 0.93 to 0.98, < 0.001]. Furthermore, the HRs of all-cause mortality in the underweight, overweight and moderate obesity groups were 1.31 (1.05, 1.64), 0.89 (0.73, 1.08) and 0.64 (0.44, 0.92), respectively in the confounder model relative to the normal weight group. Survival analysis further confirmed this inverse association of the four BMI categories with mortality. BMI was negatively associated with all-cause mortality in southern Chinese adults without morbid obesity. Compared to the normal weight category, adults in the moderate obesity category had lower all-cause mortality, whereas being underweight was associated with increased all-cause mortality.
这项前瞻性研究调查了中国非病态肥胖成年人的体重指数（BMI）与全因死亡率之间的关系。我们前瞻性地研究了12608名年龄≥35岁的中国南方成年人在2013 - 2014年至2019 - 2020年参与国家重点研发计划期间，BMI与全因死亡率之间的关系。采用Cox比例风险模型来检验BMI与全因死亡率之间的关联。体重过轻、正常体重、超重和中度肥胖的患病率分别为7.36%、55.83%、28.51%和8.31%。在中位随访期5.61年期间，共发生683例（5.65%）死亡。Cox比例风险模型表明，BMI的连续水平与全因死亡率呈负相关[每增加1kg/m²的调整风险比（HR）：0.96，95%置信区间0.93至0.98，P<0.001]。此外，在混杂因素模型中，相对于正常体重组，体重过轻、超重和中度肥胖组的全因死亡率HR分别为1.31（1.05，1.64）、0.89（0.73，1.08）和0.64（0.44，0.92）。生存分析进一步证实了这四种BMI类别与死亡率之间的这种负相关关系。在中国南方非病态肥胖成年人中，BMI与全因死亡率呈负相关。与正常体重类别相比，中度肥胖类别的成年人全因死亡率较低，而体重过轻与全因死亡率增加有关。
