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β-酰基三（羟甲基）氨基甲烷的合成、超分子组装及热致相行为

Synthesis, supramolecular organization and thermotropic phase behaviour of -acyltris(hydroxymethyl)aminomethane.

作者信息

Megarajan Sengan, Subramaniyan Siva Bala, Muthuswamy Sureshan, Anthony Savarimuthu Philip, Arunachalam Jothi, Moon Dohyun, Veerappan Anbazhagan

机构信息

School of Chemical and Biotechnology, SASTRA Deemed University Thanjavur - 613401 Tamil Nadu India

Beamline Department, Pohang Accelerator Laboratory 80 Jigokro-127 beongil, Nam-gu Pohang Korea

出版信息

RSC Adv. 2018 Sep 21;8(57):32823-32831. doi: 10.1039/c8ra06479b. eCollection 2018 Sep 18.

DOI:10.1039/c8ra06479b
PMID:35547689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9086375/
Abstract

Herein, we reported the supramolecular organization of -acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B.

摘要

在此，我们报道了N-酰基三（羟甲基）氨基甲烷（NATM）在固态以及水溶液中的超分子结构。单晶X射线衍射表明NATM呈现出完全相互穿插的结构。通过差示扫描量热法测定了与NATM热致相行为相关的热力学参数。用劳丹和普罗丹荧光分析的NATM的分子堆积和相态支持了在水溶液中形成相互穿插相。通过包封模型药物罗丹明B证明了自组装NATM囊泡的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4969/9086375/de0e1c01b78f/c8ra06479b-f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4969/9086375/de0e1c01b78f/c8ra06479b-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4969/9086375/e244b48b5edc/c8ra06479b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4969/9086375/3f27b2cb3bcf/c8ra06479b-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4969/9086375/de0e1c01b78f/c8ra06479b-f7.jpg

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