Vandenheuvel W J
Xenobiotica. 1987 Mar;17(3):397-412. doi: 10.3109/00498258709043947.
This article surveys the role of stable isotope labelling and mass spectrometric detection in the recognition and characterization of drug metabolites. Applications of the so-called isotope cluster technique, useful for both recognition of drug-related compounds and elucidation of their structures, are presented. The use of deuterium-labelled g.l.c./mass spectrometric derivatization reagents to facilitate the determination of drug metabolite structures via 'peak shifts' is illustrated.
本文综述了稳定同位素标记和质谱检测在药物代谢物识别与表征中的作用。介绍了所谓的同位素簇技术的应用，该技术对药物相关化合物的识别及其结构的阐明均有用。举例说明了使用氘标记的气相色谱/质谱衍生试剂通过“峰位移”来促进药物代谢物结构的测定。
