Shida H, Morimoto M, Inokawa K, Tsugane J, Ikeda Y
J Cardiovasc Surg (Torino). 1979 Mar-Apr;20(2):135-44.
Two hundred fifty patients more than 2 years of age having correction of congenital heart diseases by simple deep hypothermia alone were investigated in respect to metabolic abnormalities, post-operative complications, intellectual development and postoperative EEGs. LOS in lethal complications was attributed to the difficulty of resuscitation, indicating the application of this method is ideal for patients less than 6 years in age or less than 20 kg in weight. No impairment of intellectual development was observed when compared IQ before the operation and at the time of long term follow-up in serial study, but electroencephalographic assessment indicated that postoperative abnormalities might occur more frequently than previously suspected. Conclusively, it would appear that hypothermic intracardiac surgery is a safe method, provided circulatory arrest time is not allowed to exceed a limited period and the procedure is reasonably performed having a good understanding in the pathophysiology of hypothermia.
对250例2岁以上仅采用单纯深度低温矫正先天性心脏病的患者进行了代谢异常、术后并发症、智力发育及术后脑电图方面的研究。致命并发症的死亡原因是复苏困难,这表明该方法适用于6岁以下或体重不足20公斤的患者。在系列研究中,对手术前和长期随访时的智商进行比较,未观察到智力发育受损,但脑电图评估表明,术后异常的发生频率可能比之前怀疑的更高。总之,低温心脏手术似乎是一种安全的方法,前提是循环阻断时间不超过限定时间,并且在充分了解低温病理生理学的情况下合理进行手术。