甲基化途径中的基因变异对胃癌的易感性。

Susceptibility of Genetic Variations in Methylation Pathway to Gastric Cancer.

作者信息

Xiong Mengqiu, Pan Bei, Wang Xuhong, Nie Junjie, Pan Yuqin, Sun Huiling, Xu Tao, Cho William C S, Wang Shukui, He Bangshun

机构信息

Clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China.

Medical College, Southeast University, Nanjing, 210006, People's Republic of China.

出版信息

Pharmgenomics Pers Med. 2022 May 4;15:441-448. doi: 10.2147/PGPM.S340941. eCollection 2022.

DOI:10.2147/PGPM.S340941

PMID:35548064

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9081620/

Abstract

BACKGROUND

DNA methylation in the CpG island is associated with gastric cancer, genetic variations residue in genes involved in methylation pathway could contribute to the occurrence of gastric cancer. Here, we investigated the association between (), genetic variations and gastric cancer risk and patients' survival.

PATIENTS AND METHODS

We recruited 490 gastric cancer patients and 488 age- and sex-matched healthy controls. The genotypes of the genetic variations were detected by a Mass-array platform. A commercial () immunogold testing kit was used to determine the infection.

RESULTS

We found that carriers of rs2228612C allele was associated with decreased gastric cancer risk (CT vs. TT: adjusted OR = 0.70, 95% CI = 0.53-0.94, = 0.02; CT/CC vs.TT: adjusted OR = 0.73, 95% CI = 0.56-0.96, = 0.02). Further stratified analysis showed that rs2228612 CT/CC were associated with a decreased gastric cancer risk in the subgroups of age ≤64 years old (adjusted OR = 0.61, 95% CI = 0.41-0.90, = 0.01), male (adjusted OR = 0.72, 95% CI = 0.53-0.98, = 0.03), negative infection (adjusted OR = 0.67, 95% CI = 0.45-0.98, = 0.04), tumor stage T3-T4 (adjusted OR = 0.69, 95% CI = 0.51-0.92, = 0.01), and non-gastric cardiac adenocarcinoma (NGCA) (adjusted OR = 0.72, 95% CI = 0.54-0.97, = 0.03). However, none of the genetic variations of this study was associated with overall survival.

CONCLUSION

We concluded that the rs2228612C genotype is a protective factor for gastric cancer in Han Chinese population.

摘要

背景

CpG岛中的DNA甲基化与胃癌相关，参与甲基化途径的基因中的遗传变异可能促成胃癌的发生。在此，我们研究了（）、遗传变异与胃癌风险及患者生存之间的关联。

患者与方法

我们招募了490例胃癌患者和488例年龄及性别匹配的健康对照。通过Mass-array平台检测遗传变异的基因型。使用商用（）免疫金检测试剂盒确定（）感染情况。

结果

我们发现rs2228612 C等位基因携带者与胃癌风险降低相关（CT与TT相比：调整后OR = 0.70，95% CI = 0.53 - 0.94，P = 0.02；CT/CC与TT相比：调整后OR = 0.73，95% CI = 0.56 - 0.96，P = 0.02）。进一步分层分析显示，rs2228612 CT/CC在年龄≤64岁亚组（调整后OR = 0.61，95% CI = 0.41 - 0.90，P = 0.01）、男性（调整后OR = 0.72，95% CI = 0.53 - 0.98，P = 0.03）、（）感染阴性亚组（调整后OR = 0.67，95% CI = 0.45 - 0.98，P = 0.04）、肿瘤分期T3 - T4亚组（调整后OR = 0.69，95% CI = 0.51 - 0.92，P = 0.01）以及非贲门腺癌（NGCA）亚组（调整后OR = 0.72，95% CI = 0.54 - 0.97，P = 0.03）中与胃癌风险降低相关。然而，本研究中的遗传变异均与总生存无关。