He Bangshun, Pan Bei, Pan Yuqin, Sun Huiling, Xu Tao, Qin Jian, Xu Xueni, Wang Shukui
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University Nanjing, China.
Helicobacter Pylori Research Key Laboratory, Nanjing Medical University Nanjing, China.
Am J Transl Res. 2019 Jun 15;11(6):3698-3706. eCollection 2019.
The IL-4/IL-4R and IL-6/IL-6R signaling pathways are involved in immune response and play roles in gastric carcinogenesis. To investigate the association between and genetic variations and gastric cancer risk, and their prognostic values, we performed a case-control study. The genotypes of the genetic variations were detected using a Mass-array platform. The infection status was determined using a commercial immunogold testing kit. We found that the rs1800796 G allele was associated with an increased risk of gastric cancer (GG CC: OR = 2.20, 95% CI = 1.33-3.63; GG/CG CC: OR = 1.41, 95% CI = 1.09-1.82). The stratified analysis showed that rs1800796 G allele carriers (GG/CG) were associated with an increased risk of gastric cancer in the following subgroups: age >64 years old (OR = 1.67, 95% CI = 1.17-2.39), female (OR = 1.82, 95% CI = 1.09-3.05), positive for infection (OR = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR = 1.45, 95% CI = 1.08-1.96). None of the genetic variations were associated with overall survival. In short, we concluded that the rs1800796 GG genotype is a risk factor for gastric cancer and that rs1800796 G allele carriers have an increased risk of gastric cancer; this association was stronger in individuals that were >64 years old, female, or positive for infection. None of the genetic variations were associated with gastric cancer prognosis.
IL-4/IL-4R和IL-6/IL-6R信号通路参与免疫反应，并在胃癌发生过程中发挥作用。为了研究[此处原文缺失部分基因名称]基因变异与胃癌风险之间的关联及其预后价值，我们进行了一项病例对照研究。使用Mass-array平台检测基因变异的基因型。使用商用[此处原文缺失检测病原体名称]免疫金检测试剂盒确定[此处原文缺失病原体名称]感染状态。我们发现，[此处原文缺失部分基因名称]rs1800796 G等位基因与胃癌风险增加相关（GG对CC：OR = 2.20，95%CI = 1.33 - 3.63；GG/CG对CC：OR = 1.41，95%CI = 1.09 - 1.82）。分层分析表明，rs1800796 G等位基因携带者（GG/CG）在以下亚组中与胃癌风险增加相关：年龄>64岁（OR = 1.67，95%CI = 1.17 - 2.39）、女性（OR = 1.82，95%CI = 1.09 - 3.05）、[此处原文缺失病原体名称]感染阳性（OR = 1.54，95%CI = 1.07 - 2.22）、非贲门胃癌（OR = 1.53，95%CI = 1.15 - 2.04）、T3 - T4期肿瘤（OR = 1.41，95%CI = 1.06 - 1.88）以及中高分化胃癌（OR = 1.45，95%CI = 1.08 - 1.96）。这些基因变异均与总生存期无关。简而言之，我们得出结论，[此处原文缺失部分基因名称]rs1800796 GG基因型是胃癌的一个危险因素，rs1800796 G等位基因携带者患胃癌的风险增加；这种关联在年龄>64岁、女性或[此处原文缺失病原体名称]感染阳性的个体中更强。这些基因变异均与胃癌预后无关。
