Li Juan, Yang Shengmei, Yu Jiaqi, Cui Rongli, Liu Ru, Lei Runhong, Chang Yanan, Geng Huan, Qin Yanxia, Gu Weihong, Xia Shibo, Chen Kui, Kong Jianglong, Chen Guogang, Wu Chongming, Xing Gengmei
CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Science (CAS) Beijing 100049 China
Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193 China
RSC Adv. 2018 Sep 6;8(55):31366-31371. doi: 10.1039/c8ra06058d. eCollection 2018 Sep 5.
Graphene oxide (GO) suspensions can act as a good dispersant and drug delivery system for effective dispersion and drug sustained release. In this study, we investigated the impact of GO on blood/liver lipids and gut microbiota structure in high-fat diet (HFD)-induced hyperlipidemic mice. Oral administration of GO for 28 days remarkably decreased the lipid levels in blood and liver GO did not decrease the total number of gut bacteria but increased the relative abundance of short-chain fatty acid (SCFA)-producing bacteria such as clusters IV and spp. GO also enhanced the copying of bacterial butyryl coenzyme A transferase (BcoA), a key butyrate-producing gene. Although further pharmacological studies are still needed, these results provided an interesting hint that GO may exert beneficial effects on the host's metabolism selective modulation of SCFA-producing gut microbes.
氧化石墨烯（GO）悬浮液可作为一种良好的分散剂和药物递送系统，用于有效分散和药物缓释。在本研究中，我们调查了GO对高脂饮食（HFD）诱导的高脂血症小鼠血液/肝脏脂质和肠道微生物群结构的影响。口服GO 28天可显著降低血液和肝脏中的脂质水平。GO并未减少肠道细菌总数，但增加了产生短链脂肪酸（SCFA）的细菌的相对丰度，如IV簇和 spp。GO还增强了细菌丁酰辅酶A转移酶（BcoA）的复制，这是一个关键的产生丁酸盐的基因。尽管仍需要进一步的药理学研究，但这些结果提供了一个有趣的线索，即GO可能通过对产生SCFA的肠道微生物的选择性调节，对宿主代谢产生有益影响。
