Haas Aylin S, Shi Dongbo, Greb Thomas
Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.
RIKEN Center for Sustainable Resource Science (CSRS), Tsurumi-Yokohama, Japan.
Front Plant Sci. 2022 Apr 25;13:864422. doi: 10.3389/fpls.2022.864422. eCollection 2022.
Precise coordination of cell fate decisions is a hallmark of multicellular organisms. Especially in tissues with non-stereotypic anatomies, dynamic communication between developing cells is vital for ensuring functional tissue organization. Radial plant growth is driven by a plant stem cell niche known as vascular cambium, usually strictly producing secondary xylem (wood) inward and secondary phloem (bast) outward, two important structures serving as much-needed CO depositories and building materials. Because of its bidirectional nature and its developmental plasticity, the vascular cambium serves as an instructive paradigm for investigating principles of tissue patterning. Although genes and hormones involved in xylem and phloem formation have been identified, we have a yet incomplete picture of the initial steps of cell fate transitions of stem cell daughters into xylem and phloem progenitors. In this mini-review perspective, we describe two possible scenarios of cell fate decisions based on the current knowledge about gene regulatory networks and how cellular environments are established. In addition, we point out further possible research directions.
细胞命运决定的精确协调是多细胞生物的一个标志。特别是在解剖结构无固定模式的组织中，发育中的细胞之间的动态通讯对于确保功能性组织的构建至关重要。植物的径向生长由一种称为维管形成层的植物干细胞龛驱动，维管形成层通常严格地向内产生次生木质部（木材），向外产生次生韧皮部（韧皮），这两种重要结构是急需的碳储存库和建筑材料。由于维管形成层具有双向性和发育可塑性，它为研究组织模式形成的原理提供了一个具有指导意义的范例。尽管已经鉴定出参与木质部和韧皮部形成的基因和激素，但我们对干细胞子代向木质部和韧皮部祖细胞的细胞命运转变的初始步骤仍了解不完整。在这篇小型综述中，我们基于目前关于基因调控网络以及细胞环境如何建立的知识，描述了细胞命运决定的两种可能情况。此外，我们指出了进一步可能的研究方向。
