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水合桑色素在生理溶液中的溶解度、稳定性及降解动力学测定

Determination of solubility, stability and degradation kinetics of morin hydrate in physiological solutions.

作者信息

Jangid Ashok Kumar, Pooja Deep, Kulhari Hitesh

机构信息

School of Nano Sciences, Central University of Gujarat Gandhinagar 382030 India

Pharmacology and Toxicology Division, CSIR-Indian Institute of Chemical Technology Hyderabad-500007 India.

出版信息

RSC Adv. 2018 Aug 14;8(50):28836-28842. doi: 10.1039/c8ra04139c. eCollection 2018 Aug 7.

DOI:10.1039/c8ra04139c
PMID:35548393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9084450/
Abstract

Natural drugs have emerged as potential alternatives to synthetic drugs to avoid their toxic effects. Morin hydrate (MH) is a natural therapeutic agent, obtained from , and . Solubility and degradation kinetics of morin hydrate in different physiological media, namely, 0.1 N HCl (pH 1.2), sodium acetate buffer (pH 5.0), water (pH 7.0), phosphate buffer saline (pH 7.4) and tris base (pH 9.0), were investigated classical spectroscopic methods. Stability studies of MH were performed to determine the effect of different pH media, temperature (room and freeze) and light on the degradation kinetics. Solubility and stability of MH varied significantly in different biological media and storage conditions. Solubility of MH was pH-dependent and increased with the increase in pH. Degradation kinetics and regression values ( ) values were calculated from the linear fitted models of zero, first and second order kinetics.

摘要

天然药物已成为合成药物的潜在替代品，以避免其毒性作用。水合桑色素（MH）是一种天然治疗剂，从[具体来源未给出]获得。采用经典光谱方法研究了水合桑色素在不同生理介质中的溶解度和降解动力学，这些介质包括0.1 N HCl（pH 1.2）、醋酸钠缓冲液（pH 5.0）、水（pH 7.0）、磷酸盐缓冲盐水（pH 7.4）和三羟甲基氨基甲烷（pH 9.0）。进行了MH的稳定性研究，以确定不同pH介质、温度（室温与冷冻）和光照对降解动力学的影响。MH的溶解度和稳定性在不同生物介质和储存条件下有显著差异。MH的溶解度依赖于pH，并随pH升高而增加。从零级、一级和二级动力学的线性拟合模型计算降解动力学和回归值（[具体回归值未给出]）。

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