Doğan Yusuf, Öziç Cem, Ertaş Erdal, Baran Ayşe, Rosic Gvozden, Selakovic Dragica, Eftekhari Aziz
Kızıltepe Vocational School, Mardin Artuklu University, Mardin, Türkiye.
Department of Basic Medical Sciences, Department of Medical Biology, Faculty of Medicine, Kafkas University, Kars, Türkiye.
Front Chem. 2024 Oct 21;12:1477724. doi: 10.3389/fchem.2024.1477724. eCollection 2024.
Cancer is a major disease that affects millions of people around the world every year. It affects individuals of all ages, races, and backgrounds. Since drugs used to treat cancer cannot distinguish between cancerous and healthy cells, they cause systemic toxicity along with serious side effects. Recently, controlled drug-release systems have been developed to reduce the side effects caused by anticancer drugs used for treatment. Morin is an anticancer drug with a flavonol structure. It has been extensively researched for its antioxidant, anti-inflammatory, antitumoral, and antibacterial properties, especially found in Chinese herbs and fruits, and its multiple positive effects on different diseases. In this study, a nanocomposite with magnetic properties was synthesized by coating biocompatible activated carbon obtained using the fruits of the plant on the surface of iron oxide magnetic nanoparticles. Characterization of the synthesized activated carbon-coated iron oxide magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction, dynamic light scattering, zeta potential, and vibrating sample magnetometry. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (colorectal), T98-G (glioblastoma) cancer cell lines, and human umbilical vein endothelial cell (HUVEC) healthy cell line. The morin loading and release behavior of the activated carbon-coated iron oxide magnetic nanocomposite were studied, and the results showed that up to 60% of the adsorbed morin was released within 4 h. In summary, activated carbon-coated iron oxide magnetic nanocomposite carriers have shown promising results for the delivery of the morin drug.
癌症是一种主要疾病，每年影响着全球数百万人。它影响着各个年龄、种族和背景的人。由于用于治疗癌症的药物无法区分癌细胞和健康细胞，它们会导致全身毒性以及严重的副作用。最近，已开发出控释药物系统以减少用于治疗的抗癌药物所引起的副作用。桑色素是一种具有黄酮醇结构的抗癌药物。它因其抗氧化、抗炎、抗肿瘤和抗菌特性而受到广泛研究，尤其存在于中草药和水果中，并且对不同疾病具有多种积极作用。在本研究中，通过将使用该植物果实获得的生物相容性活性炭包覆在氧化铁磁性纳米颗粒表面，合成了一种具有磁性的纳米复合材料。通过傅里叶变换红外光谱、扫描电子显微镜、能量色散X射线光谱、X射线衍射、动态光散射、zeta电位和振动样品磁强计对合成的活性炭包覆氧化铁磁性纳米复合材料进行了表征确认。在HT - 29（结肠直肠癌）、T98 - G（胶质母细胞瘤）癌细胞系和人脐静脉内皮细胞（HUVEC）健康细胞系中检测了载药磁性纳米复合材料的细胞毒性作用。研究了活性炭包覆氧化铁磁性纳米复合材料的桑色素负载和释放行为，结果表明，在4小时内，高达60%吸附的桑色素被释放出来。总之，活性炭包覆氧化铁磁性纳米复合载体在桑色素药物递送方面已显示出有前景的结果。
