Vorob'eva L I, Ol'sinskaia N L, Naumova E S, Dubinin A V, Shemchuk L F
Zh Mikrobiol Epidemiol Immunobiol. 1987 Feb(2):7-12.
The possibility of detecting propionic acid-producing bacteria in the intestine of healthy humans with a view to obtaining a strain which is physiologically most suitable for therapeutic purposes has been studied. The selective conditions for the isolation of propionic acid-producing bacteria from the large intestine have been experimentally established. Analysis of 70 puncture biopsy specimens of parietal mucus and luminal contents from different sections of the intestine has not shown the presence of the representatives of propionic acid-producing bacteria. The strains isolated under the conditions selective for such bacteria have been found to belong to the family Enterobacteriaceae. These strains have proved capable of synthesizing vitamin B12, but the synthesis of propionic acid has not been observed.
为了获得一种在生理上最适合治疗目的的菌株,对在健康人体肠道中检测产丙酸细菌的可能性进行了研究。已经通过实验确定了从大肠中分离产丙酸细菌的选择性条件。对来自肠道不同部位的70份壁层黏液和管腔内容物穿刺活检标本的分析未显示产丙酸细菌的存在。在对这类细菌有选择性的条件下分离出的菌株被发现属于肠杆菌科。这些菌株已被证明能够合成维生素B12,但未观察到丙酸的合成。